L. Boglione, F. Poletti, R. Rostagno, R. Moglia, M. Cantone, M. Esposito, Cristina Scianguetta, Beatrice Domenicale, Fortunata Di Pasquale, S. Borrè
{"title":"住院患者随访2年后的长期新冠肺炎综合征","authors":"L. Boglione, F. Poletti, R. Rostagno, R. Moglia, M. Cantone, M. Esposito, Cristina Scianguetta, Beatrice Domenicale, Fortunata Di Pasquale, S. Borrè","doi":"10.21037/jphe-22-66","DOIUrl":null,"url":null,"abstract":"Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic affected many leading to higher mortality and morbidity worldwide. The post-COVID syndrome (PCS) is characterized by heterogeneous group of clinical manifestations which can frequently lead to a significant worsening in everyday life, working and social conditions. Methods: We prospectively examined in a cohort of patients discharged from our hospital \"Saint Andrea”, Vercelli, Italy, from 10th March 2020 to 15th January 2021, with COVID-19 diagnosis during the first wave of pandemic the prevalence and characteristics of PCS after 2 years of follow-up. Results: Overall included patients were 306;prevalence of PCS after 2 years was 43.8%;the fatigue assessment scale (FAS) evidenced that only 8.5% of patients suffered from a severe fatigue with important limitations. Most frequently observed symptoms/conditions were: fatigue (38.2%), breathlessness (19.3%), \"brain fog” (29.7%), sleeping disorders (28.8%), post-traumatic stress disorder (29.4%), anxiety (39.9%);only 7.2% of patients resumed the work without limitations or rest period. In multivariate analysis intensive care unit (ICU) admission [odds ratio (OR) =3.950;95% confidence interval (CI): 2.466–8.112;P=0.002], length of hospitalization (OR =1.855;95% CI: 1.248–5.223;P=0.004) and nosocomial infections (OR =2.556;95% CI: 1.443–5.292;P<0.001) were predictive of PCS at 2 years in the study population. Conclusions: After 2 years of follow-up, the 43.8% of enrolled subjects suffered from the PCS, but only the 8.5% with severe limitations in everyday life. We expect these data to highlight the importance of clinical and non-clinical aspect following the PCS in hospitalized patients. © Journal of Public Health and Emergency. All rights reserved.","PeriodicalId":92257,"journal":{"name":"Journal of public health and emergency","volume":" ","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Long-COVID syndrome in hospitalized patients after 2 years of follow-up\",\"authors\":\"L. Boglione, F. Poletti, R. Rostagno, R. Moglia, M. Cantone, M. Esposito, Cristina Scianguetta, Beatrice Domenicale, Fortunata Di Pasquale, S. Borrè\",\"doi\":\"10.21037/jphe-22-66\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic affected many leading to higher mortality and morbidity worldwide. The post-COVID syndrome (PCS) is characterized by heterogeneous group of clinical manifestations which can frequently lead to a significant worsening in everyday life, working and social conditions. Methods: We prospectively examined in a cohort of patients discharged from our hospital \\\"Saint Andrea”, Vercelli, Italy, from 10th March 2020 to 15th January 2021, with COVID-19 diagnosis during the first wave of pandemic the prevalence and characteristics of PCS after 2 years of follow-up. Results: Overall included patients were 306;prevalence of PCS after 2 years was 43.8%;the fatigue assessment scale (FAS) evidenced that only 8.5% of patients suffered from a severe fatigue with important limitations. Most frequently observed symptoms/conditions were: fatigue (38.2%), breathlessness (19.3%), \\\"brain fog” (29.7%), sleeping disorders (28.8%), post-traumatic stress disorder (29.4%), anxiety (39.9%);only 7.2% of patients resumed the work without limitations or rest period. In multivariate analysis intensive care unit (ICU) admission [odds ratio (OR) =3.950;95% confidence interval (CI): 2.466–8.112;P=0.002], length of hospitalization (OR =1.855;95% CI: 1.248–5.223;P=0.004) and nosocomial infections (OR =2.556;95% CI: 1.443–5.292;P<0.001) were predictive of PCS at 2 years in the study population. Conclusions: After 2 years of follow-up, the 43.8% of enrolled subjects suffered from the PCS, but only the 8.5% with severe limitations in everyday life. We expect these data to highlight the importance of clinical and non-clinical aspect following the PCS in hospitalized patients. © Journal of Public Health and Emergency. All rights reserved.\",\"PeriodicalId\":92257,\"journal\":{\"name\":\"Journal of public health and emergency\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of public health and emergency\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21037/jphe-22-66\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of public health and emergency","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21037/jphe-22-66","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Long-COVID syndrome in hospitalized patients after 2 years of follow-up
Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic affected many leading to higher mortality and morbidity worldwide. The post-COVID syndrome (PCS) is characterized by heterogeneous group of clinical manifestations which can frequently lead to a significant worsening in everyday life, working and social conditions. Methods: We prospectively examined in a cohort of patients discharged from our hospital "Saint Andrea”, Vercelli, Italy, from 10th March 2020 to 15th January 2021, with COVID-19 diagnosis during the first wave of pandemic the prevalence and characteristics of PCS after 2 years of follow-up. Results: Overall included patients were 306;prevalence of PCS after 2 years was 43.8%;the fatigue assessment scale (FAS) evidenced that only 8.5% of patients suffered from a severe fatigue with important limitations. Most frequently observed symptoms/conditions were: fatigue (38.2%), breathlessness (19.3%), "brain fog” (29.7%), sleeping disorders (28.8%), post-traumatic stress disorder (29.4%), anxiety (39.9%);only 7.2% of patients resumed the work without limitations or rest period. In multivariate analysis intensive care unit (ICU) admission [odds ratio (OR) =3.950;95% confidence interval (CI): 2.466–8.112;P=0.002], length of hospitalization (OR =1.855;95% CI: 1.248–5.223;P=0.004) and nosocomial infections (OR =2.556;95% CI: 1.443–5.292;P<0.001) were predictive of PCS at 2 years in the study population. Conclusions: After 2 years of follow-up, the 43.8% of enrolled subjects suffered from the PCS, but only the 8.5% with severe limitations in everyday life. We expect these data to highlight the importance of clinical and non-clinical aspect following the PCS in hospitalized patients. © Journal of Public Health and Emergency. All rights reserved.