D. Nachira, M. Chiappetta, E. Zanfrini, E. Meacci, M. Congedo, F. Lococo, M. Vita, L. Petracca-Ciavarella, D. Tabacco, C. Sassorossi, V. Porziella, S. Margaritora
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Mediastinal up-staging: risk factors and prognosis: a narrative review
Mediastinal nodal upstaging after surgical resection for nonsmall cell lung cancer (NSCLC) is defined as the finding of mediastinal node disease (pN2) at pathological staging in presumed clinical N0-1 tumors (1,2). Pathological mediastinal lymph node involvement is one of the most important prognostic factors in NSCLC and the main determinant for adjuvant therapy after surgery. The aim of this review is to analyze the principal risk factors for mediastinal nodal upstaging and to evaluate the prognostic implications for patients affected by NSCLC. Review Article
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