脊柱表皮样肿瘤——一种罕见且无症状的发生

L. Cardoso, R. Nogueira, Lino Fonseca, A. Nabais
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摘要

目的:表皮样肿瘤是一种生长缓慢的、以鳞状上皮为衬里的良性病变。是罕见的,常见于颅内和脊髓硬膜内的表皮样瘤极为罕见。作者建议描述一个手术患者的临床病例。方法:我们报告一名75岁男性,腰骶部CT扫描显示腰4- l5椎管狭窄伴左L4-L5椎间孔狭窄,因腰椎滑脱而就诊神经外科。神经学检查显示步态跛行,痉挛性截瘫,左侧肌肉力量3-/5,右侧肌肉力量4+/5。左侧深腱反射增加,伴有髌骨和踝关节阵挛,但右侧正常。左下D5皮区,感觉失敏。MRI显示硬膜内病变,D6水平明显为髓外病变。该病变确定了明显的脊髓压迫,在所有MRI检查中与脑脊液有相同的信号。患者行D5椎板切除术和正中线状硬膜切开术,发现硬膜内肿瘤(珍珠白色),靠近蛛网膜,可从脊髓中剥离。全部切除。结果:术后患者临床稳定,无新发缺损。随访第4个月,患者逐渐恢复,肌肉力量等级为4/5。组织病理学显示角蛋白片样,大体钙化灶,符合表皮样瘤的诊断。结论:这个病例表明,即使是一种罕见的病理,我们也必须在我们的临床推理中发现它,这样我们才能正确诊断它。它也揭示了一个病例的相关病理的脊柱,这可能延误诊断,增加了永久性神经功能障碍恶化的风险。手术的目的始终是完全切除,因此,由于其良性,复发率低,患者在临床上可能会好转,可以认为治愈。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Spinal Epidermoid Tumor – A Rare and Silent Occurrence
Objective: Epidermoid tumors are slow-growing benign lesions lined by squamous epithelium. Are rare, commonly intracranial and spinal intradural epidermoid tumors are extremely rare. The authors propose to describe a clinical case of a patient operated. Methods: We report a 75-year-old male referred to neurosurgical consultation by spondylolisthesis at L4-L5 with stenotic spinal canal and a left L4-L5 foraminal stenosis, revealed by lumbosacral CT scan. Neurologic exam revealed a claudicant gait, spastic paraparesis with muscular strenght of 3-/5 at left and 4+/5 at right. Deep tendon reflexes were increased at left with presence of patelar and ankle clonus, but normally at right. Below left D5 dermatome, he had sensory parestesia. MRI showed an intradural lesion, apparently exclusively extra-medullary at D6 level. This lesion determines a significant spinal cord compression and had identical signal to the CSF in all MRI ponderations. It was performed a D5 laminectomy and median linear durotomy with identification of an intradural tumor (pearl-white color), adjacent to the arachnoid, dissectable from spine cord. Gross total resection was achieved. Results: Postoperatively the patient remained clinically stable and without new deficits. At the 4th month of follow-up the patient progressively recovered and was presenting with muscle strength grade 4/5. Histopathology showed a sample of keratin lamellae, foci of gross calcification, compatible with diagnosis of epidermoid tumor. Conclusion: This case demonstrates that even being a rare pathology we must have it present in our clinical reasoning so we can diagnose it properly. It also reveals a case of associated pathology of the spine, which could delay the diagnosis, increasing the risk of worsening of permanent neurological deficit. The goal is always the complete surgical resection and so, because of is benign nature and low rate of recurrence the patients may improve clinically and can be considered cured.
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