胍丁氨酸和胆碱治疗AlCl3和强迫游泳应激所致认知障碍大鼠的比较疗效。

IF 3.2 Q2 Pharmacology, Toxicology and Pharmaceutics
Hira Rafi, Fahad Ahmad, Javaria Anis, Ruba Khan, Hamna Rafiq, Muhammad Farhan
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引用次数: 2

摘要

目的内源性胍丁胺作为一种神经递质在学习记忆过程中具有重要作用。各种研究描述了内源性胍丁胺在多种认知任务的学习和记忆中的生理作用,表明在大鼠大脑的学习过程中胍丁胺水平升高。在人类受试者中,胆碱的饮食摄入与认知功能相关,胆碱补充剂的治疗证实了减少学习和认知障碍痴呆的能力。方法36只大鼠平均分为三组,每组接受以下治疗:a.对照组口服水,b.胍丁胺(p.o.)100mg/Kg/体重,c.胆碱(p.o。行为在光/暗盒、开放场、新型物体识别测试(NOR)中进行评估,T迷宫测试和Morris水迷宫测试。结果与补充胆碱相比,给予胍丁胺的动物在亮/暗盒和正方形交叉的明亮区域花费的时间增加,同时在学习和记忆范式中观察到Morris水迷津和T迷宫测试中的空间记忆改善,以及NOR中新物体的辨别能力增强。结论本研究确定,与胆碱补充剂相比,(100mg/kg/BW)剂量的胍丁胺治疗可减轻导致行为障碍和缺陷的记忆和认知障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative effectiveness of Agmatine and Choline treatment in rats with cognitive impairment induced by AlCl3 and Forced Swim Stress.
AIM Endogenous agmatine has a significant role in learning and memory process as a neurotransmitter. Various studies described the physiological role of endogenous agmatine in learning and memory of multiple cognitive tasks suggesting elevated levels of agmatine during learning process in rat brain. Dietary intake of choline shown correlation with cognitive functions in human subjects and treatment with choline supplements validated the ability to diminish learning and cognitive impairment dementias. METHOD 36 rats were equally divided into three groups each that received the following treatments: a. water was given orally to control group b. Agmatine (p.o.) 100 mg/Kg/Body Weight and c. Choline (p.o.) 100 mg/Kg/Body Weight daily for 14 days. Behaviors were assessed in Light/Dark Box, Open Field, Novel Object Recognition Test (NOR), T Maze Test and Morris Water Maze Test. RESULTS Animals administered with agmatine demonstrated increased time spent in bright area of light/dark box and square crossed while improved spatial memory in Morris water maze and T maze test and enhanced discrimination of novel object in NOR were observed in learning and memory paradigms as compared with choline supplement. CONCLUSION Present study determines that agmatine treatment at the dose of (100 mg/kg/BW) attenuate memory and cognitive impairment that leads to behavioral disorders and deficits in comparison with choline supplements.
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来源期刊
Current clinical pharmacology
Current clinical pharmacology PHARMACOLOGY & PHARMACY-
CiteScore
3.60
自引率
0.00%
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0
期刊介绍: Current Clinical Pharmacology publishes frontier reviews on all the latest advances in clinical pharmacology. The journal"s aim is to publish the highest quality review articles in the field. Topics covered include: pharmacokinetics; therapeutic trials; adverse drug reactions; drug interactions; drug metabolism; pharmacoepidemiology; and drug development. The journal is essential reading for all researchers in clinical pharmacology.
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