Hira Rafi, Fahad Ahmad, Javaria Anis, Ruba Khan, Hamna Rafiq, Muhammad Farhan
{"title":"胍丁氨酸和胆碱治疗AlCl3和强迫游泳应激所致认知障碍大鼠的比较疗效。","authors":"Hira Rafi, Fahad Ahmad, Javaria Anis, Ruba Khan, Hamna Rafiq, Muhammad Farhan","doi":"10.2174/1574884714666191016152143","DOIUrl":null,"url":null,"abstract":"AIM\nEndogenous agmatine has a significant role in learning and memory process as a neurotransmitter. Various studies described the physiological role of endogenous agmatine in learning and memory of multiple cognitive tasks suggesting elevated levels of agmatine during learning process in rat brain. Dietary intake of choline shown correlation with cognitive functions in human subjects and treatment with choline supplements validated the ability to diminish learning and cognitive impairment dementias.\n\n\nMETHOD\n36 rats were equally divided into three groups each that received the following treatments: a. water was given orally to control group b. Agmatine (p.o.) 100 mg/Kg/Body Weight and c. Choline (p.o.) 100 mg/Kg/Body Weight daily for 14 days. Behaviors were assessed in Light/Dark Box, Open Field, Novel Object Recognition Test (NOR), T Maze Test and Morris Water Maze Test.\n\n\nRESULTS\nAnimals administered with agmatine demonstrated increased time spent in bright area of light/dark box and square crossed while improved spatial memory in Morris water maze and T maze test and enhanced discrimination of novel object in NOR were observed in learning and memory paradigms as compared with choline supplement.\n\n\nCONCLUSION\nPresent study determines that agmatine treatment at the dose of (100 mg/kg/BW) attenuate memory and cognitive impairment that leads to behavioral disorders and deficits in comparison with choline supplements.","PeriodicalId":10746,"journal":{"name":"Current clinical pharmacology","volume":" ","pages":""},"PeriodicalIF":3.2000,"publicationDate":"2020-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1574884714666191016152143","citationCount":"2","resultStr":"{\"title\":\"Comparative effectiveness of Agmatine and Choline treatment in rats with cognitive impairment induced by AlCl3 and Forced Swim Stress.\",\"authors\":\"Hira Rafi, Fahad Ahmad, Javaria Anis, Ruba Khan, Hamna Rafiq, Muhammad Farhan\",\"doi\":\"10.2174/1574884714666191016152143\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"AIM\\nEndogenous agmatine has a significant role in learning and memory process as a neurotransmitter. Various studies described the physiological role of endogenous agmatine in learning and memory of multiple cognitive tasks suggesting elevated levels of agmatine during learning process in rat brain. Dietary intake of choline shown correlation with cognitive functions in human subjects and treatment with choline supplements validated the ability to diminish learning and cognitive impairment dementias.\\n\\n\\nMETHOD\\n36 rats were equally divided into three groups each that received the following treatments: a. water was given orally to control group b. Agmatine (p.o.) 100 mg/Kg/Body Weight and c. Choline (p.o.) 100 mg/Kg/Body Weight daily for 14 days. Behaviors were assessed in Light/Dark Box, Open Field, Novel Object Recognition Test (NOR), T Maze Test and Morris Water Maze Test.\\n\\n\\nRESULTS\\nAnimals administered with agmatine demonstrated increased time spent in bright area of light/dark box and square crossed while improved spatial memory in Morris water maze and T maze test and enhanced discrimination of novel object in NOR were observed in learning and memory paradigms as compared with choline supplement.\\n\\n\\nCONCLUSION\\nPresent study determines that agmatine treatment at the dose of (100 mg/kg/BW) attenuate memory and cognitive impairment that leads to behavioral disorders and deficits in comparison with choline supplements.\",\"PeriodicalId\":10746,\"journal\":{\"name\":\"Current clinical pharmacology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2020-08-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.2174/1574884714666191016152143\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current clinical pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1574884714666191016152143\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current clinical pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1574884714666191016152143","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
Comparative effectiveness of Agmatine and Choline treatment in rats with cognitive impairment induced by AlCl3 and Forced Swim Stress.
AIM
Endogenous agmatine has a significant role in learning and memory process as a neurotransmitter. Various studies described the physiological role of endogenous agmatine in learning and memory of multiple cognitive tasks suggesting elevated levels of agmatine during learning process in rat brain. Dietary intake of choline shown correlation with cognitive functions in human subjects and treatment with choline supplements validated the ability to diminish learning and cognitive impairment dementias.
METHOD
36 rats were equally divided into three groups each that received the following treatments: a. water was given orally to control group b. Agmatine (p.o.) 100 mg/Kg/Body Weight and c. Choline (p.o.) 100 mg/Kg/Body Weight daily for 14 days. Behaviors were assessed in Light/Dark Box, Open Field, Novel Object Recognition Test (NOR), T Maze Test and Morris Water Maze Test.
RESULTS
Animals administered with agmatine demonstrated increased time spent in bright area of light/dark box and square crossed while improved spatial memory in Morris water maze and T maze test and enhanced discrimination of novel object in NOR were observed in learning and memory paradigms as compared with choline supplement.
CONCLUSION
Present study determines that agmatine treatment at the dose of (100 mg/kg/BW) attenuate memory and cognitive impairment that leads to behavioral disorders and deficits in comparison with choline supplements.
期刊介绍:
Current Clinical Pharmacology publishes frontier reviews on all the latest advances in clinical pharmacology. The journal"s aim is to publish the highest quality review articles in the field. Topics covered include: pharmacokinetics; therapeutic trials; adverse drug reactions; drug interactions; drug metabolism; pharmacoepidemiology; and drug development. The journal is essential reading for all researchers in clinical pharmacology.