口服液体药物筛选装置的评估

IF 0.2 Q4 MEDICINE, LEGAL
D. Beirness, D. R. Smith
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引用次数: 18

摘要

本项目旨在研究接触点(POC)口服液药物筛选装置,以确定此类装置在加拿大执行药物受损驾驶中的潜在适用性。研究人员从一组承认最近服用过药物的人以及一些没有服用过药物的人身上收集了口服液样本。这些样本在三种口服液筛查装置中的一种上进行了测试,以确定大麻、可卡因、安非他明、甲基苯丙胺、阿片类药物和苯二氮卓类药物的存在。每位参与者还提供了第二份口服液样本,送往参比实验室进行独立分析。将口腔液筛查装置的结果与实验室分析的结果进行比较,提供了对六种药物/药物类别中每种药物的敏感性和特异性的估计。大麻、可卡因、甲基苯丙胺和阿片类药物的敏感性超过0.80。这些药物/药物类别的假阳性率均在3%至7%之间。所有药物/药物类别的特异性均超过0.90。这些发现表明,在加拿大,口腔液体筛查可能被证明是检测司机吸毒的一种有价值的工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An assessment of oral fluid drug screening devices
ABSTRACT This project was to examine point-of-contact (POC) oral fluid drug screening devices to determine the suitability of such devices for potential use in the enforcement of drug-impaired driving in Canada. Oral fluid samples were collected from a group of individuals who admitted to having recently ingested drugs as well as a number of individuals who had not been using drugs. These samples were tested on one of three oral fluid screening devices to determine the presence of cannabis, cocaine, amphetamine, methamphetamine, opioids, and benzodiazepines. Each participant also provided a second oral fluid sample that was sent to a reference laboratory for independent analysis. Comparison of the results from the oral fluid screening device and those from the laboratory analysis provided estimates of sensitivity and specificity for each of the six drugs/drug categories. Sensitivity exceeded 0.80 for cannabis, cocaine, methamphetamine, and opioids. False positive rates for these drugs/drug categories were all between 3% and 7%. Specificity exceeded 0.90 for all drugs/drug categories. These findings indicate that oral fluid screening could prove to be a valuable tool in the detection of driver drug use in Canada.
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来源期刊
CiteScore
1.00
自引率
0.00%
发文量
21
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