铁基生物可吸收支架的慢性毒性和致癌性研究

IF 6.1 3区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Xiaoli Shi, Lu Zhang, Yan-fei Liu, Jinyu Wang, Gui Zhang, Haiping Qi, Wanqian Zhang, Deyuan Zhang, Jin Wang
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引用次数: 0

摘要

摘要铁基支架以其良好的力学性能和生物相容性,适当的强度-延性组合,在生物可降解支架中占有重要地位。虽然铁的腐蚀速率不理想,但通过引入铁合金和聚合物涂层对其进行了优化。铁基支架作为一种可长期植入的生物降解材料,其真正关注的主要是长期的生物安全性。本研究以大鼠为动物模型,研究铁基支架的慢性毒性和致癌性。两年后监测实验期间的体重变化和生理状态,并结合主要脏器健康和组织病理学检查进行血常规和血液分析。结果表明,与对照组(316L SS)相比,体重、血常规指标、血液生化指标、致癌率均无显著差异,进一步证实了铁基材料的生物安全性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Study on the chronic toxicity and carcinogenicity of iron-based bioabsorbable stents
Abstract Fe-based stents have been made a figure in biodegradable stents by their good mechanical capacity and biocompatibility, appropriate strength–ductility combination. Although the iron corrosion rate was not ideal, which had been optimized by iron alloy and polymer coating introduction. As a long-term implanted biodegradable material, the real concern about iron-based stents mainly laid in long-term biosafety. In this work, rats were used as an animal model to study the chronic toxicity and carcinogenicity of iron-based stents. Two years later, the changes in body weight and the physiological status during the experiment were monitored, and the blood routine and blood analysis combined with the health of major organs and histopathological tests were performed. The results demonstrated that there was no significant difference compared with the control group (316L SS) in body weight, blood routine index, blood biochemical index, and carcinogenic rate that further confirmed the biosafety of iron-based material.
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来源期刊
Nanotechnology Reviews
Nanotechnology Reviews CHEMISTRY, MULTIDISCIPLINARY-NANOSCIENCE & NANOTECHNOLOGY
CiteScore
11.40
自引率
13.50%
发文量
137
审稿时长
7 weeks
期刊介绍: The bimonthly journal Nanotechnology Reviews provides a platform for scientists and engineers of all involved disciplines to exchange important recent research on fundamental as well as applied aspects. While expert reviews provide a state of the art assessment on a specific topic, research highlight contributions present most recent and novel findings. In addition to technical contributions, Nanotechnology Reviews publishes articles on implications of nanotechnology for society, environment, education, intellectual property, industry, and politics.
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