蓍草抗氧化活性、总酚含量、酶抑制及抗癌特性的研究

IF 1.3 4区工程技术 Q4 CHEMISTRY, ANALYTICAL

Instrumentation Science & Technology Pub Date : 2022-05-17 DOI:10.1080/10739149.2022.2073369

N. Karaaslan Ayhan, Merve Gökşin Karaaslan Tunç, S. Noma, Ali Kuruçay, B. Ateş

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引用次数: 1

摘要

摘要:本文对人类常用凉茶——千叶蓍草(Achillea millefolium L.， yarrow)的抗氧化活性、总酚含量、酶抑制和抗癌特性进行了研究。采用不同的提取工艺和溶剂制备了亚蓍草提取物，并确定了最佳提取条件。以抗氧化活性和总酚含量为评价指标，超声辅助提取的得率最高。产率由高到低依次为甲醇、水和乙腈。以甲醇为原料，考察了水蛭提取物的酶抑制作用和抗癌作用。抑制黄嘌呤氧化酶和乙酰胆碱酯酶的IC50值分别为4.974±0.54和21.891±1.118µg/mL。测定提取物浓度为23.85 μg/mL时，对乳腺癌细胞生长抑制活性(IC50) (MCF-7)降低50%。

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Characterization of the antioxidant activity, total phenolic content, enzyme inhibition, and anticancer properties of Achillea millefolium L. (yarrow)

Abstract The antioxidant activity, total phenolic content, enzyme inhibition, anticancer properties of Achillea millefolium L. (yarrow), which is generally consumed by humans as herbal tea, were investigated. Yarrow extracts were prepared with different extraction techniques and solvents and the optimum conditions were determined. When the antioxidant activity and total phenolic content results were evaluated, the best yield was obtained with ultrasound-assisted extraction for all solvents. Moreover, the yields from highest to lowest were methanol, water, and acetonitrile. The enzyme inhibition and anticancer of Achillea millefolium L. extracts using methanol were evaluated. The IC50 values for the inhibition of xanthine oxidase and acetylcholinesterase were 4.974 ± 0.54 and 21.891 ± 1.118 µg/mL, respectively. The extract concentration was determined to be 23.85 μg/mL for 50% reduction in growth inhibitory activity cell viability (IC50) against breast cancer (MCF-7).

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来源期刊

Instrumentation Science & Technology 工程技术-分析化学

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Instrumentation Science & Technology is an internationally acclaimed forum for fast publication of critical, peer reviewed manuscripts dealing with innovative instrument design and applications in chemistry, physics biotechnology and environmental science. Particular attention is given to state-of-the-art developments and their rapid communication to the scientific community. Emphasis is on modern instrumental concepts, though not exclusively, including detectors, sensors, data acquisition and processing, instrument control, chromatography, electrochemistry, spectroscopy of all types, electrophoresis, radiometry, relaxation methods, thermal analysis, physical property measurements, surface physics, membrane technology, microcomputer design, chip-based processes, and more. Readership includes everyone who uses instrumental techniques to conduct their research and development. They are chemists (organic, inorganic, physical, analytical, nuclear, quality control) biochemists, biotechnologists, engineers, and physicists in all of the instrumental disciplines mentioned above, in both the laboratory and chemical production environments. The journal is an important resource of instrument design and applications data.