微波辐射/回流条件下新型咪唑席夫碱衍生物的绿色合成及其抗菌活性评价

IF 0.9 Q4 CHEMISTRY, MULTIDISCIPLINARY
Samane Eftekhari, N. Foroughifar, S. Hallajian, A. Khajeh-Amiri
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引用次数: 5

摘要

席夫碱是优良的化合物。它们是由活性羰基和胺缩合合成的。它们被广泛用作制备工业化合物和制药用途的基质。它们表现出广泛的生物活动。本研究基于席夫碱的重要性,开发了一种可持续的合成方法——回流法和微波辐射法。开发了一种以乙醇为绿色溶剂,回流、微波辐射合成咪唑席夫碱衍生物的新方法。在回流和微波辐射条件下合成了咪唑席夫碱衍生物。考察了咪唑衍生物和标准药物对两种革兰氏阳性菌(金黄色葡萄球菌、枯草芽孢杆菌)和两种革兰氏阴性菌(奇异变形杆菌、大肠杆菌)的抗菌活性。评价了希夫碱对革兰氏阳性菌和革兰氏阴性菌的抗菌作用。本文采用回流、微波辐射和乙醇合成了一系列新型咪唑类希夫碱衍生物。研究了抗菌效果。微波辐射在咪唑衍生物合成中的优异优点包括将反应时间从一小时缩短到一分钟,产物产率高。在这项研究中,抗菌活性的测量也很重要。具有Cl、OH和CH3基团的咪唑衍生物显示出抗菌作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Green Synthesis of Some Novel Imidazole Schiff base Derivatives Under Microwave Irradiation / Reflux Conditions and Evaluations of the Antibacterial Activity
Schiff bases are excellent compounds. They were synthesized by condensation of active carbonyl and amines. They were widely used as a substrate in the preparation of industrial compounds as well as pharmaceutical purposes. They exhibit a wide range of biological activities. In this study, based on the importance of Schiff bases, a sustainable synthetic method was developed employing reflux and microwave irradiation. Develop a new synthetic method for imidazole Schiff base derivatives synthesis employing reflux, microwave irradiation, and ethanol as a green solvent. Synthesis of imidazole Schiff base derivatives was carried out under reflux and microwave irradiation conditions. Antibacterial activity of imidazole derivatives and standard drugs was examined against two Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis) and two Gramnegative bacteria (Proteus mirabilis, Escherichia coli). Schiff bases were synthesized in the presence of microwave irradiation and ethanol in high yields 90-98% for 2-4 min. The antibacterial effects of Schiff bases were evaluated against both strains of Gram-positive and Gram-negative. In this paper, a novel series of imidazole Schiff base derivatives were synthesized using reflux, microwave irradiation, and ethanol. Antibacterial effects were investigated. The excellent advantages of microwave irradiation in the synthesis of imidazole derivatives include reduction of reaction time from an hour to a minute, high product yield. In this study, the measurement of antibacterial activity was also important. Imidazole derivatives with Cl, OH, and CH3 groups showed antibacterial effects.
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来源期刊
Current Microwave Chemistry
Current Microwave Chemistry CHEMISTRY, MULTIDISCIPLINARY-
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