{"title":"外用药物样品中米诺地尔的电位测定","authors":"R. A. Sousa, É. Cavalheiro","doi":"10.1590/S0100-46702009000200003","DOIUrl":null,"url":null,"abstract":"A potentiometric titration method for the determination of minoxidil based on its re- dox reaction with K2Cr2O7 is described. The best results were observed using 1.00 x 10-3 mol L-1 K2Cr2O7 and 1.00 x 10-2 mol L-1 minoxidil solutions, and the minoxidil as titrant in 2.00 mol L-1 H2SO4 medium. The method was applied to commercial samples and compared with the results from a chromatographic procedure. Recoveries from 97.4 to 98.7 % were observed depending on the sample. Comparison with the chromatographic procedure reveled agreement within 90% confidence level.","PeriodicalId":35894,"journal":{"name":"Ecletica Quimica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1590/S0100-46702009000200003","citationCount":"4","resultStr":"{\"title\":\"Potentiometric determination of Minoxidil in topical use pharmaceutical samples\",\"authors\":\"R. A. Sousa, É. Cavalheiro\",\"doi\":\"10.1590/S0100-46702009000200003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A potentiometric titration method for the determination of minoxidil based on its re- dox reaction with K2Cr2O7 is described. The best results were observed using 1.00 x 10-3 mol L-1 K2Cr2O7 and 1.00 x 10-2 mol L-1 minoxidil solutions, and the minoxidil as titrant in 2.00 mol L-1 H2SO4 medium. The method was applied to commercial samples and compared with the results from a chromatographic procedure. Recoveries from 97.4 to 98.7 % were observed depending on the sample. Comparison with the chromatographic procedure reveled agreement within 90% confidence level.\",\"PeriodicalId\":35894,\"journal\":{\"name\":\"Ecletica Quimica\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-01-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1590/S0100-46702009000200003\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ecletica Quimica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1590/S0100-46702009000200003\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Physics and Astronomy\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ecletica Quimica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1590/S0100-46702009000200003","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Physics and Astronomy","Score":null,"Total":0}
引用次数: 4
摘要
基于米诺地尔与K2Cr2O7的还原反应，建立了测定米诺地尔的电位滴定法。使用1.00 x 10-3 mol L-1 K2Cr2O7和1.00 x 10-2 mol L-1的米诺地尔溶液，以及米诺地尔作为滴定剂在2.00 mol L-1H2SO4介质中观察到最佳结果。该方法应用于商业样品，并与色谱程序的结果进行了比较。根据样品的不同，回收率为97.4%至98.7%。与色谱程序的比较表明，在90%的置信水平内一致。
Potentiometric determination of Minoxidil in topical use pharmaceutical samples
A potentiometric titration method for the determination of minoxidil based on its re- dox reaction with K2Cr2O7 is described. The best results were observed using 1.00 x 10-3 mol L-1 K2Cr2O7 and 1.00 x 10-2 mol L-1 minoxidil solutions, and the minoxidil as titrant in 2.00 mol L-1 H2SO4 medium. The method was applied to commercial samples and compared with the results from a chromatographic procedure. Recoveries from 97.4 to 98.7 % were observed depending on the sample. Comparison with the chromatographic procedure reveled agreement within 90% confidence level.
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