Abemaciclib、Hymenialdisine和Indirubin分子动力学及对接对CDK-2抑制作用的模拟研究

Journal of Ardabil University of Medical Sciences Pub Date : 2022-03-01 DOI:10.52547/jarums.22.1.39

M. Asadi-Samani, N. Jamali, Javad Saffari-Chaleshtori, Korosh Ashrafi-Dehkordi

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引用次数: 0

摘要

背景与目的:细胞周期蛋白依赖性激酶2 (CDK-2)是一种丝氨酸/苏氨酸蛋白激酶，在细胞周期中具有调节活性。这种蛋白质的抑制剂是通过阻止细胞周期来治疗多种癌症的首选。本论文对Abemaciclib、Hymenialdisine的对接效应和分子动力学进行了研究

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Evaluating the Effects of Molecular Dynamic And Docking of Abemaciclib, Hymenialdisine, and Indirubin on CDK-2 Inhibition by Simulation Study

Background & objectives: Cyclin-dependent kinase 2 (CDK-2) is a serine/threonine protein kinase with regulatory activity in the cell cycle. Inhibitors of this protein are the treatment of choice for a variety of cancers by stopping the cell cycle. In this in silico study, the effects of docking and molecular dynamics of Abemaciclib, Hymenialdisine

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来源期刊

Journal of Ardabil University of Medical Sciences

自引率

0.00%

发文量

审稿时长

6 weeks