Bahareh Vard, Maryam Mahdieh, Roya Riahi, M. Heidari-Beni, R. Kelishadi
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There was a significant difference between obese and non-obese children in both α-tocopherol (pooled mean difference respectively: 0.36, 95% CI: 0.04-0.96, P<0.001 ) with non-significant heterogeneity (P>0.05, I2=0.0% ) and α-tocopherol per lipoid (pooled mean difference: 0.42, 95%CI: 0.28-0.55, P<0.001), with significant heterogeneity (P=0.048, I2=58.8%). There was no significant association between vitamin E level and obesity (pooled mean difference: 0.40, 95%CI: -0.05-0.85, P>0.05), with significant heterogeneity (P<0.001, I2=84.5%). There was significant association between zinc, magnesium, copper, and selenium level and obesity (P>0.05), with significant heterogeneity (P<0.001). Conclusions: This review revealed a significant inverse relationship between childhood obesity and serum antioxidant levels. More studies are necessary to find the underlying mechanisms and clinical impacts of this finding. Data Sources: This systematic review and meta-analysis were performed among English language articles published until September 2020 without any time limit. An electronic search was conducted in international databases of Google Scholar, PubMed, Web of Science, Scopus, Medline, and Cochrane. Study Selection: First, 1255 papers were found. After removing duplicates and quality assessment, 46 were used in the systemic review, and 19 articles were entered into the meta-analysis. Data Extraction: Two researchers independently searched the following keywords in the databases: “Vitamin C”, “Vitamin E”, “Vitamin A”, “Carotenoids”, “Antioxidants”, “Selenium”, “Magnesium”, “Copper”, “Zinc”, “Ascorbic acid”, “Tocopherol”, “Obesity”, “Overweight”, “Childhood”, “Pediatric”, and “Adolescence”. Articles that examined the association between obesity and antioxidant status were included in the study. The research on animals, interventional studies, case studies, case reports, and irrelevant studies were excluded. The research team determined the quality of studies using the STROBE (strengthening the reporting of observational studies in epidemiology) checklist. Heterogeneity of studies was evaluated using index (I2) and probability of diffusion bias by funnel plot and Begg’s and Egger’s tests.","PeriodicalId":43059,"journal":{"name":"Journal of Pediatrics Review","volume":" ","pages":""},"PeriodicalIF":0.3000,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Association Between Antioxidant Status and Excess Weight in Children: A Systematic Review and Meta-analysis\",\"authors\":\"Bahareh Vard, Maryam Mahdieh, Roya Riahi, M. Heidari-Beni, R. Kelishadi\",\"doi\":\"10.32598/JPR.9.3.962.1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: The prevalence of childhood obesity with its complications has increased in the world. Obesity, along with antioxidants deficiency (due to an unhealthy diet), might change the balance in favor of oxidative stress. Objectives: The current study aims to assess the literature on the relationship between obesity and antioxidant status through a systematic review and meta-analysis Results: β-Carotene levels was significantly lower in obese children than non-obese ones (mean difference: 0.13, 95%CI: 0.09-0.16, P<0.001), with significant heterogeneity (P<0.001, I2=85%). There was a significant difference between obese and non-obese children in both α-tocopherol (pooled mean difference respectively: 0.36, 95% CI: 0.04-0.96, P<0.001 ) with non-significant heterogeneity (P>0.05, I2=0.0% ) and α-tocopherol per lipoid (pooled mean difference: 0.42, 95%CI: 0.28-0.55, P<0.001), with significant heterogeneity (P=0.048, I2=58.8%). There was no significant association between vitamin E level and obesity (pooled mean difference: 0.40, 95%CI: -0.05-0.85, P>0.05), with significant heterogeneity (P<0.001, I2=84.5%). There was significant association between zinc, magnesium, copper, and selenium level and obesity (P>0.05), with significant heterogeneity (P<0.001). Conclusions: This review revealed a significant inverse relationship between childhood obesity and serum antioxidant levels. More studies are necessary to find the underlying mechanisms and clinical impacts of this finding. 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引用次数: 0
摘要
背景:儿童肥胖及其并发症的患病率在世界范围内呈上升趋势。肥胖,加上抗氧化剂缺乏(由于不健康的饮食),可能会改变平衡,有利于氧化应激。目的:本研究旨在通过系统回顾和荟萃分析对肥胖与抗氧化状态关系的文献进行评估。结果:肥胖儿童β-胡萝卜素水平显著低于非肥胖儿童(平均差异为0.13,95%CI: 0.09-0.16, P0.05, I2=0.0%), α-生育酚/脂质水平显著低于非肥胖儿童(汇总平均差异为0.42,95%CI: 0.28-0.55, P0.05),异质性显著(P0.05),异质性显著(P<0.001)。结论:本综述揭示了儿童肥胖与血清抗氧化水平之间的显著负相关关系。需要更多的研究来发现这一发现的潜在机制和临床影响。数据来源:本系统综述和荟萃分析是在2020年9月之前发表的英文文章中进行的,没有任何时间限制。在b谷歌Scholar、PubMed、Web of Science、Scopus、Medline和Cochrane等国际数据库中进行电子检索。研究选择:首先,共找到1255篇论文。在剔除重复和质量评估后,46篇纳入系统评价,19篇纳入meta分析。数据提取:两位研究人员在数据库中独立搜索了以下关键词:“维生素C”、“维生素E”、“维生素A”、“类胡萝卜素”、“抗氧化剂”、“硒”、“镁”、“铜”、“锌”、“抗坏血酸”、“生育酚”、“肥胖”、“超重”、“儿童”、“儿科”和“青春期”。研究中包括了研究肥胖和抗氧化状态之间关系的文章。排除了动物研究、介入性研究、病例研究、病例报告和无关研究。研究小组使用STROBE(加强流行病学观察性研究报告)检查表确定研究质量。采用指数(I2)评价研究的异质性,采用漏斗图和Begg’s和Egger’s检验评价扩散偏倚概率。
The Association Between Antioxidant Status and Excess Weight in Children: A Systematic Review and Meta-analysis
Background: The prevalence of childhood obesity with its complications has increased in the world. Obesity, along with antioxidants deficiency (due to an unhealthy diet), might change the balance in favor of oxidative stress. Objectives: The current study aims to assess the literature on the relationship between obesity and antioxidant status through a systematic review and meta-analysis Results: β-Carotene levels was significantly lower in obese children than non-obese ones (mean difference: 0.13, 95%CI: 0.09-0.16, P<0.001), with significant heterogeneity (P<0.001, I2=85%). There was a significant difference between obese and non-obese children in both α-tocopherol (pooled mean difference respectively: 0.36, 95% CI: 0.04-0.96, P<0.001 ) with non-significant heterogeneity (P>0.05, I2=0.0% ) and α-tocopherol per lipoid (pooled mean difference: 0.42, 95%CI: 0.28-0.55, P<0.001), with significant heterogeneity (P=0.048, I2=58.8%). There was no significant association between vitamin E level and obesity (pooled mean difference: 0.40, 95%CI: -0.05-0.85, P>0.05), with significant heterogeneity (P<0.001, I2=84.5%). There was significant association between zinc, magnesium, copper, and selenium level and obesity (P>0.05), with significant heterogeneity (P<0.001). Conclusions: This review revealed a significant inverse relationship between childhood obesity and serum antioxidant levels. More studies are necessary to find the underlying mechanisms and clinical impacts of this finding. Data Sources: This systematic review and meta-analysis were performed among English language articles published until September 2020 without any time limit. An electronic search was conducted in international databases of Google Scholar, PubMed, Web of Science, Scopus, Medline, and Cochrane. Study Selection: First, 1255 papers were found. After removing duplicates and quality assessment, 46 were used in the systemic review, and 19 articles were entered into the meta-analysis. Data Extraction: Two researchers independently searched the following keywords in the databases: “Vitamin C”, “Vitamin E”, “Vitamin A”, “Carotenoids”, “Antioxidants”, “Selenium”, “Magnesium”, “Copper”, “Zinc”, “Ascorbic acid”, “Tocopherol”, “Obesity”, “Overweight”, “Childhood”, “Pediatric”, and “Adolescence”. Articles that examined the association between obesity and antioxidant status were included in the study. The research on animals, interventional studies, case studies, case reports, and irrelevant studies were excluded. The research team determined the quality of studies using the STROBE (strengthening the reporting of observational studies in epidemiology) checklist. Heterogeneity of studies was evaluated using index (I2) and probability of diffusion bias by funnel plot and Begg’s and Egger’s tests.