年龄对ercp后胰腺炎及其严重程度的影响

Q4 Medicine

中华肝胆外科杂志 Pub Date : 2019-12-28 DOI:10.3760/CMA.J.ISSN.1007-8118.2019.12.010

Fei Liu, Bo Liu, C. Qi, Yu-long Yang, Jing-yi Li, Mei-ju Lin, Yue-feng Ma

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引用次数: 0

摘要

目的研究衰老对ERCP术后胰腺炎（PEP）患者胰腺萎缩、纤维化和外分泌低功能的影响及其严重程度。方法对2011年6月至2018年4月在大连大学附属中山医院接受ERCP的786例患者进行回顾性研究。75岁以上的患者被分为老年组，而75岁以下的患者则被分为年轻组。分析两组ERCP术后胰腺炎的发生率和严重程度。结果老年组308例。平均年龄（81.8±4.8）岁。在年轻组中，有478名患者。平均年龄（57.7±12.0）岁。老年组的平均手术时间为（52.5±14.1）分钟，年轻组为（50.7±14.9）分钟。两组手术时间及相关因素无显著性差异（P>0.05），高淀粉酶血症发生率无显著性差别（29.9%vs30.1%，P>0.05），PEP总发生率为11.3%（89/786）。老年组PEP发生率为6.5%（20/308），明显低于年轻组（χ2=11.765，P<0.05）；老年组轻、中、重度PEP的发生率均明显低于年轻对照组（均P<0.05）。结论老龄化（≥75岁）可导致胰腺萎缩、纤维化、外分泌功能减退，对PEP有保护作用。关键词：胰腺炎；高淀粉酶血症；胰胆管造影，内镜逆行；黄疸，梗阻性；胆道狭窄

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The impact of aging on post-ERCP pancreatitis and its severity

Objective To study the impact of aging on pancreatic atrophy, fibrosis and exocrine hypofunction in patients with post-ERCP pancreatitis (PEP) and its severity. Methods A retrospective study was conducted on 786 patients who underwent ERCP at the Affiliated Zhongshan Hospital of Dalian University from June 2011 to April 2018. Patients who were aged over 75 years were grouped into the elderly group while those aged less than 75 years were grouped into the younger group. The incidences and severity of post-ERCP pancreatitis in the two groups were analyzed. Results In the elderly group, there were 308 patients. The average age was (81.8±4.8) years. In the younger group, there were 478 patients. The average age was (57.7±12.0) years. The average operation time for the elderly group was (52.5±14.1) minutes, and that for the younger group was (50.7±14.9) minutes. There were no significant differences in operation time and in the related factors between the two groups (P>0.05). There was no significant difference in the rates of hyperamylasemia between the two groups (29.9% vs 30.1%, P>0.05). The overall rate of PEP was 11.3% (89/786). In the elderly group, the rate of PEP was 6.5% (20/308), which was significantly lower than that in the younger group (χ2=11.765, P<0.05). The rates of mild, moderate and severe PEP in the elderly group was significantly lower than those in the younger group (all P<0.05). Hyperamylasemia and pancreatitis in the 2 groups were alleviated after conservative treatment. Conclusions Aging (≥75 years) resulted in pancreatic atrophy, fibrosis, exocrine hypofunction which had a protective effect on PEP. Key words: Pancreatitis; Hyperamylasemia; Cholangiopancreatography, endoscopic retrograde; Jaundice, obstructive; Biliary strictures

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来源期刊

中华肝胆外科杂志 Medicine-Gastroenterology

CiteScore

0.20

自引率

0.00%

发文量

7101

期刊介绍： Chinese Journal of Hepatobiliary Surgery is an academic journal organized by the Chinese Medical Association and supervised by the China Association for Science and Technology, founded in 1995. The journal has the following columns: review, hot spotlight, academic thinking, thesis, experimental research, short thesis, case report, synthesis, etc. The journal has been recognized by Beida Journal (Chinese Journal of Humanities and Social Sciences). Chinese Journal of Hepatobiliary Surgery has been included in famous databases such as Peking University Journal (Chinese Journal of Humanities and Social Sciences), CSCD Source Journals of China Science Citation Database (with Extended Version) and so on, and it is one of the national key academic journals under the supervision of China Association for Science and Technology.