石鸡吉对醋酸致溃疡性结肠炎雄性大鼠促炎和抗炎细胞因子水平的影响

Q3 Medicine

Journal of Medicinal Plants Pub Date : 2020-09-01 DOI:10.29252/jmp.19.75.78

Fatemeh Alimahdi, N. Shahrokhi, M. Hadad, Gholamerza Asadikaram, M. Abolhasani

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引用次数: 0

摘要

背景:溃疡性结肠炎患者结肠中IL-13、IL-4、IL-1B、TNF-α和IL-10水平发生改变。既往研究发现，shilajit(沥青)对溃疡性结肠炎有改善作用。我们猜测shilajit能够通过影响细胞因子的数量来改善溃疡性结肠炎。目的:探讨希拉吉特对溃疡性结肠炎患者IL-13、IL-4、IL-1B、TNF-α、IL-10的影响。方法:在本实验研究中，49白7组结肠炎患者，灌胃希拉吉，结肠炎结果:与灌胃药组相比，灌胃希拉吉组IL-10、il -4、IL-1β、TNF-α升高。假手术组IL-4、IL-13、IL-10、TNF-α水平降至正常水平。结论:考虑到大鼠的肠道代谢水平低于它，可以表明它已经能够更低更合适的改变

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Effect of shilajit on the levels of pro-inflammatory and anti inflammatory cytokines in ulcerative colitis induced by acetic acid in male rats

Background: The levels of IL-13, IL-4, IL-1B, TNF-α and IL-10 alter in the colon of people with ulcerative colitis. previous studies, it was found that shilajit (asphaltum) was effective in the improvement of ulcerative colitis.we guessed that the shilajit has been able to improve the ulcerative colitis by affecting the amount of cytokines. Objective: The aim of the present study was to investigate the effects of shilajit on IL-13, IL-4, IL-1B, TNF-α and IL-10 in ulcerative colitis. Methods: In this experimental study, 49 white 7 groups colitis, Gavage shilajit, colitis Results: The Gavage shilajit group increased IL-10, IL-4and IL-1β, TNF-α compared to Gavage vehicle group. Shilajit able to close the levels of IL-4, IL-13, IL-10, TNF-α to normal values the sham group. Conclusion: Considering that the of intestinal the of rat the shilajit lower than it can be shown that shilajit has been able to more reduce more suitable change in

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来源期刊

Journal of Medicinal Plants Medicine-Complementary and Alternative Medicine

CiteScore

1.60

自引率

0.00%

发文量

期刊介绍： The Journal of Medicinal Plants is published quarterly. This journal contains articles in the fields of basic and clinical sciences related to medicinal plants including pharmacognosy, basic and clinical pharmacology, basic and clinical toxicology, and pharmacology.