除草剂对抗乙酰辅酶a羧化酶抑制剂抗性的新可能性

IF 3.5 Q1 AGRONOMY
Bikash Kumar Rajak, Priyanka Rani, Pranabesh Mandal, R. S. Chhokar, Nitesh Singh, Durg Vijay Singh
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引用次数: 1

摘要

乙酰辅酶a羧化酶(Acetyl-CoA carboxylase, ACCase: EC 6.4.1.2)是植物合成和伸长脂肪酸所必需的含生物素酶之一。这种独特的酶在所有禾本科植物家族中都以同质形式存在,使其成为开发针对禾本科杂草的除草剂的合适靶点。一个这样的例子是在冬小麦作物田里的小Phalaris侵扰,其中芳氧苯氧丙酸酯(FOP);采用环己二酮类(DIM)和苯基吡唑啉类(DEN)抗ACCase除草剂。然而,越来越多的抗ACCase除草剂杂草种群迫使农业科学家寻求通过综合杂草管理(IWM)策略来控制杂草的各种可能性。开发新的潜在除草剂来恢复杂草的敏感性可能是控制杂草的方法。当前计算技术的进步可以通过探索作物和杂草中除草剂作用催化位点的基因组学、蛋白质组学和结构细节来帮助开发新的类除草剂分子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Emerging possibilities in the advancement of herbicides to combat acetyl-CoA carboxylase inhibitor resistance
Acetyl-CoA carboxylase (ACCase: EC 6.4.1.2) is one of the essential biotins containing enzymes required by plants for fatty acid synthesis and elongation. The unique enzyme is present in its homomeric form in all the Gramineae family, making it a suitable target for developing herbicides selectively against weeds of the Gramineae family. One such example is infestation of Phalaris minor in winter wheat crop fields, where aryloxyphenoxypropionates (FOP); cyclohexanediones (DIM) and phenyl pyrazoline (DEN) group of ACCase inhibiting herbicides are used. However, the increasing number of ACCase herbicide resistant weed populations has compelled agro-scientists to seek varied possibilities for weed control, through Integrated Weed Management (IWM) strategies. Developing new potential herbicides to regain sensitivity in weeds could be an approach to weed control. The current advancement in computational techniques could be of aid in developing new herbicide-like molecules by exploring the genomics, proteomics and structural details of catalytic sites of herbicide action in crops as well as weeds.
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来源期刊
Frontiers in Agronomy
Frontiers in Agronomy Agricultural and Biological Sciences-Agricultural and Biological Sciences (miscellaneous)
CiteScore
4.80
自引率
0.00%
发文量
123
审稿时长
13 weeks
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