问题信息

Current Protocols in Microbiology Pub Date : 2020-12-25 DOI:10.1002/cpmc.85

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引用次数: 0

摘要

封面:在Grabowski和Kissinger等人(http://doi.org/10.1002/cpmc.118)中，该图像显示来自唾液腺和中肠的蜱虫蛋白质为对策开发提供了理想的目标。通过LC-MS/MS蛋白质组学，唾液腺中的许多蛋白质可以在血液摄食过程中分泌，并在摄食部位和形成的水泥锥中发现。中肠蛋白，特别是暴露在管腔中的蛋白，为病原体相互作用提供了关键区域，并可能有助于病原体通过中肠上皮层传播，从而全身感染蜱。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Issue Information

Cover: In Grabowski and Kissinger et al. (http://doi.org/10.1002/cpmc.118), the image shows tick proteins from salivary glands and midguts provide ideal targets for countermeasure development. By using LC-MS/MS proteomics, proteins can be profiled from salivary glands, many of which can be secreted during blood feeding and found within the feeding site and the formed cement cone. Midgut proteins, especially exposed proteins in the lumen, provide critical areas for pathogen interactions and may aid in pathogen dissemination through the midgut epithelial layer to systemically infect the tick.

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来源期刊

Current Protocols in Microbiology Immunology and Microbiology-Parasitology

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期刊介绍： Current Protocols in Microbiology provides detailed, step-by-step instructions for analyzing bacteria, animal and plant viruses, fungi, protozoans and other microbes. It offers updated coverage of emerging technologies and concepts, such as biofilms, quorum sensing and quantitative PCR, as well as proteomic and genomic methods. It is the first comprehensive source of high-quality microbiology protocols that reflects and incorporates the new mandates and capabilities of this robust and rapidly evolving discipline.