孟加拉人群谷胱甘肽S -转移酶(M1和T1)和血管紧张素转换酶基因多态性与慢性肾病

IF 0.8 Q4 GENETICS & HEREDITY
Jakaria Shawon , Md. Mostafijur Rahman , Zabun Nahar , Yearul Kabir
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引用次数: 1

摘要

慢性肾脏疾病(CKD)是一个世界性的公共卫生问题,影响着大量的个体,并被记录为一个全球性的公共卫生问题。本研究旨在揭示孟加拉人群谷胱甘肽S -转移酶M1 (GSTM1, rs366631)、谷胱甘肽S -转移酶T1 (GSTT1, rs17856199)、血管紧张素转换酶-插入/缺失(ce - i /D, rs4646994)和细胞色素P450家族11亚家族B成员2 - 344 T/C (CYP11B2 - 344 T/C, rs1799998)基因多态性与CKD发生风险的关系。专家抽血师从355名参与者(175名CKD患者和180名健康对照)中抽取血样。基因多态性分析采用了不同的技术,如等位基因特异性多重PCR(聚合酶链反应)、等位基因特异性PCR和PCR- rflp(聚合酶链反应-限制性片段长度多态性)。GSTT1零基因型显著相关(OR = 2.45;95% ci = 1.56-3.82;p & lt;0.001), GSTM1-GSTT1联合零基因型(OR = 4.16;95% ci = 1.99-8.64;p & lt;0.001)和ACE- I/D基因纯合突变变体(DD) (OR = 4.60;95% ci = 1.77-12.00;p & lt;0.01)。发现ACE- I/D多态性的纯合突变变体(DD)在男性CKD受试者中更为普遍。从我们的研究结果可以看出,GSTT1零基因型、GSTM1-GSTT1联合零基因型和ACE- I/D纯合突变变体(DD)可能与CKD易感性相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Glutathione S -transferase (M1 and T1) and angiotensin-converting enzyme gene polymorphisms and chronic kidney disease in Bangladeshi population

Chronic kidney disease (CKD) is a worldwide public health problem that affects a huge number of individuals and documented as a global public health problem. This study was conducted to uncover the association of gene polymorphism of Glutathione S -transferase M1 (GSTM1, rs366631), Glutathione S -transferase T1 (GSTT1, rs17856199), Angiotensin converting enzyme- Insertion/Deletion (ACE-I/D, rs4646994), and Cytochrome P450 Family 11 Subfamily B Member 2 − 344 T/C (CYP11B2 − 344 T/C, rs1799998) with the risk of development of CKD in Bangladeshi population. Blood samples were drawn from 355 participants (175 CKD patients and 180 healthy controls) by an expert phlebotomist. Different techniques like allele-specific multiplex PCR (Polymerase chain reaction), allele-specific PCR, and PCR-RFLP (Polymerase chain reaction-restriction fragment length polymorphism) were used for the genetic polymorphism analysis. Significant associations were evident for GSTT1 null genotype (OR = 2.45; 95% CI = 1.56–3.82; p < 0.001), combined GSTM1-GSTT1 null genotype (OR = 4.16; 95% CI = 1.99–8.64; p < 0.001) and homozygous mutant variant (DD) of ACE- I/D gene (OR = 4.60; 95% CI = 1.77–12.00; p < 0.01). Homozygous mutant variant (DD) of ACE- I/D polymorphism was found to be more prevalent in the male CKD subjects. It is apparent from our findings that the null genotype of GSTT1, combined GSTM1-GSTT1 null genotype, and homozygous mutant variant (DD) of ACE- I/D could be associated with CKD susceptibility.

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来源期刊
Meta Gene
Meta Gene Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
1.10
自引率
0.00%
发文量
20
期刊介绍: Meta Gene publishes meta-analysis, polymorphism and population study papers that are relevant to both human and non-human species. Examples include but are not limited to: (Relevant to human specimens): 1Meta-Analysis Papers - statistical reviews of the published literature of human genetic variation (typically linked to medical conditionals and/or congenital diseases) 2Genome Wide Association Studies (GWAS) - examination of large patient cohorts to identify common genetic factors that influence health and disease 3Human Genetics Papers - original studies describing new data on genetic variation in smaller patient populations 4Genetic Case Reports - short communications describing novel and in formative genetic mutations or chromosomal aberrations (e.g., probands) in very small demographic groups (e.g., family or unique ethnic group). (Relevant to non-human specimens): 1Small Genome Papers - Analysis of genetic variation in organelle genomes (e.g., mitochondrial DNA) 2Microbiota Papers - Analysis of microbiological variation through analysis of DNA sequencing in different biological environments 3Ecological Diversity Papers - Geographical distribution of genetic diversity of zoological or botanical species.
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