布洛芬透皮凝胶的配方与评价:促透剂与微针的应用

Q4 Pharmacology, Toxicology and Pharmaceutics
R. Parhi, S. Goutam, S. Mondal
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引用次数: 1

摘要

本研究的目的是在生物黏附强度、凝胶强度、展布性、黏度和药物释放研究等体外评价参数的基础上,采用不同聚合物单独和组合制备布洛芬凝胶,并选择最佳凝胶配方。选择的凝胶配方由羟丙基甲基纤维素(HPMC K100M)和羧甲基纤维素钠(NaCMC)各1% (w/w)组成。采用化学方法(以1,8-桉树脑为化学渗透促进剂)和物理方法(微针)两种方法提高IBP在大鼠腹部皮肤的渗透。在两种技术中,后一种技术与对照相比具有更高的渗透增强(2.865倍)。此外,当两种技术同时使用时,还观察到协同效应,渗透率提高了3.307倍。角叉菜胶诱导大鼠足跖水肿的体内抗炎研究和甩尾法大鼠模型镇痛活性研究显示,与口服组相比,持续作用可达8 h。在室内和加速条件下进行了三个月的稳定性研究,没有显示出任何不稳定的迹象。因此,开发的IBP凝胶是稳定的,并且在经皮给药时具有潜在的抗炎和镇痛作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Formulation and Evaluation of Transdermal Gel of Ibuprofen: Use of Penetration Enhancer and Microneedle
The objective of the current study was to develop Ibuprofen (IBP) gel using different polymers individually and in combination and then to select best gel formulation based on various in-vitro evaluation parameters such as bioadhesive strength, gel strength, spreadability, viscosity and drug release study. The selected gel formulation was found to be composed of 1% (w/w) each of hydroxypropyl methylcellulose (HPMC K100M) and sodium carboxy methylcellulose (NaCMC). Two techniques such as chemical method using 1,8-cineole as chemical penetration enhancer (CPE) and physical technique using microneedle were employed to improve IBP permeation across the abdominal skin of rat. Out of the two techniques, the later technique showed higher (2.865-fold) permeation enhancement compared to control. Furthermore, a synergistic effect was also observed when both the techniques were used simultaneously with 3.307-fold increase in permeation enhancement. In-vivo anti-inflammatory study on rats induced with carrageenan paw oedema and analgesic activity investigation by tail flick method in rat model exhibited sustained effect up to 8 h compared to orally treated group. The stability study at room and accelerated conditions for three months did not show any sign of instability. Thus, the developed IBP gel is stable and have potential to illicit both anti-inflammatory and analgesic effect when administered transdermally.
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来源期刊
Iranian Journal of Pharmaceutical Sciences
Iranian Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
0.50
自引率
0.00%
发文量
0
期刊介绍: Iranian Journal of Pharmaceutical Sciences (IJPS) is an open access, internationally peer-reviewed journal that seeks to publish research articles in different pharmaceutical sciences subdivisions: pharmacology and toxicology, nanotechnology, pharmaceutics, natural products, biotechnology, pharmaceutical chemistry, clinical pharmacy and other pharmacy related topics. Each issue of the journal contents 16 outstanding research articles in area of pharmaceutical sciences plus an editorial written by the IJPS editors on one of the most up to date advances topics in pharmacy. All articles published by IJPS would be permanently accessible online freely without any subscription charges. Authors of the published articles have granted the right to use and disseminate their article to third parties.
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