{"title":"高唾液酸化促进肿瘤免疫逃逸","authors":"M. Cui, Q. Liao","doi":"10.3760/CMA.J.ISSN.1001-9030.2019.12.054","DOIUrl":null,"url":null,"abstract":"Sialylation is one type of glycosylation that adds sialic acid residues to the tip of glycans in glycoprotein or glycolipid on cell membrane and participates in many critical cellular processes via cell-cell contact. The level of sialylation is usually elevated during carcinogenesis. Increased sialic acid could interact with Siglecs on the surface of immune cells, and thus induce immunosuppressive tumor microenvironment and tumor immune escape. It is believed that sialic acid-Siglecs can be served as novel immune checkpoints and bring hope to the development of immunotherapy in the future. \n \n \nKey words: \nSialic acid; Cancer; Immune escape; Siglec","PeriodicalId":10065,"journal":{"name":"中华实验外科杂志","volume":"36 1","pages":"2295-2298"},"PeriodicalIF":0.0000,"publicationDate":"2019-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hypersialylation promotes tumor immune escape\",\"authors\":\"M. Cui, Q. Liao\",\"doi\":\"10.3760/CMA.J.ISSN.1001-9030.2019.12.054\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Sialylation is one type of glycosylation that adds sialic acid residues to the tip of glycans in glycoprotein or glycolipid on cell membrane and participates in many critical cellular processes via cell-cell contact. The level of sialylation is usually elevated during carcinogenesis. Increased sialic acid could interact with Siglecs on the surface of immune cells, and thus induce immunosuppressive tumor microenvironment and tumor immune escape. It is believed that sialic acid-Siglecs can be served as novel immune checkpoints and bring hope to the development of immunotherapy in the future. \\n \\n \\nKey words: \\nSialic acid; Cancer; Immune escape; Siglec\",\"PeriodicalId\":10065,\"journal\":{\"name\":\"中华实验外科杂志\",\"volume\":\"36 1\",\"pages\":\"2295-2298\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-12-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中华实验外科杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1001-9030.2019.12.054\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华实验外科杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1001-9030.2019.12.054","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Sialylation is one type of glycosylation that adds sialic acid residues to the tip of glycans in glycoprotein or glycolipid on cell membrane and participates in many critical cellular processes via cell-cell contact. The level of sialylation is usually elevated during carcinogenesis. Increased sialic acid could interact with Siglecs on the surface of immune cells, and thus induce immunosuppressive tumor microenvironment and tumor immune escape. It is believed that sialic acid-Siglecs can be served as novel immune checkpoints and bring hope to the development of immunotherapy in the future.
Key words:
Sialic acid; Cancer; Immune escape; Siglec
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
