{"title":"血管造影患者血清维生素D、维生素K和骨钙素浓度与冠状动脉粥样硬化的协同关联评估","authors":"Zahra Elyaspour , Samad Akbarzadeh , Daryoush Iranpour , Niloofar Motemed , Najme Hajian , Afshar Bargahei , Ali Movahed","doi":"10.1016/j.jnim.2018.12.002","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>The aim of this study was to assess the association between serum concentration of vitamin D, vitamin K, and osteocalcin with coronary atherosclerosis in patients undergoing angiography.</p></div><div><h3>Design</h3><p>In this case-control study, 138 people who referred to Bushehr Heart Center for routine examination participated. Demographic information of the participants was registered by using a standard questionnaire. Before undergoing the angiographic processes, venous blood samples were obtained via venipuncture from the antecubital vein into gel and clot activator tubes and stored at – 80 °C until the analysis. After the angiography process was over, the normal participants entered the control group and those with coronary atherosclerosis plaque placed in the case group. Finally, serum levels of vitamin K2 and Osteocalcin were measured in the samples, by using ELISA kits and the serum level of vitamin D was measured by using HPLC.</p></div><div><h3>Result</h3><p>serum levels of vitamin D in the case group were significantly lower than in the control (p = 0.009) and, serum levels of osteocalcin in the case group were significantly higher than in the control (P = 0.019). There was no difference in K2 level between the two groups (P = 0.84). By separating the three factors like age, sex and T2DM in the two groups, a significant synergistic was found between the concentration of osteocalcin, vitamin D (just in <20 ng/ml) and coronary atherosclerosis (p = 0.025, p = 0.029 respectively). Further, an association was observed between vitamin D level and the severity of atherosclerosis (P = 0.041).).</p></div><div><h3>Conclusion</h3><p>the results of this study suggest that the increase in the level of osteocalcin and the deficiency of vitamin D is significantly associated with coronary atherosclerosis but, not with vitamin k2. Moreover, serum vitamin D concentration is associated with severity of coronary atherosclerosis.</p></div>","PeriodicalId":91757,"journal":{"name":"Journal of nutrition & intermediary metabolism","volume":"15 ","pages":"Pages 78-83"},"PeriodicalIF":0.0000,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jnim.2018.12.002","citationCount":"0","resultStr":"{\"title\":\"Assessment of the synergistic association of serum concentration of vitamin D, vitamin K and osteocalcin with coronary atherosclerosis in patients undergoing angiography\",\"authors\":\"Zahra Elyaspour , Samad Akbarzadeh , Daryoush Iranpour , Niloofar Motemed , Najme Hajian , Afshar Bargahei , Ali Movahed\",\"doi\":\"10.1016/j.jnim.2018.12.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>The aim of this study was to assess the association between serum concentration of vitamin D, vitamin K, and osteocalcin with coronary atherosclerosis in patients undergoing angiography.</p></div><div><h3>Design</h3><p>In this case-control study, 138 people who referred to Bushehr Heart Center for routine examination participated. Demographic information of the participants was registered by using a standard questionnaire. Before undergoing the angiographic processes, venous blood samples were obtained via venipuncture from the antecubital vein into gel and clot activator tubes and stored at – 80 °C until the analysis. After the angiography process was over, the normal participants entered the control group and those with coronary atherosclerosis plaque placed in the case group. Finally, serum levels of vitamin K2 and Osteocalcin were measured in the samples, by using ELISA kits and the serum level of vitamin D was measured by using HPLC.</p></div><div><h3>Result</h3><p>serum levels of vitamin D in the case group were significantly lower than in the control (p = 0.009) and, serum levels of osteocalcin in the case group were significantly higher than in the control (P = 0.019). There was no difference in K2 level between the two groups (P = 0.84). By separating the three factors like age, sex and T2DM in the two groups, a significant synergistic was found between the concentration of osteocalcin, vitamin D (just in <20 ng/ml) and coronary atherosclerosis (p = 0.025, p = 0.029 respectively). Further, an association was observed between vitamin D level and the severity of atherosclerosis (P = 0.041).).</p></div><div><h3>Conclusion</h3><p>the results of this study suggest that the increase in the level of osteocalcin and the deficiency of vitamin D is significantly associated with coronary atherosclerosis but, not with vitamin k2. Moreover, serum vitamin D concentration is associated with severity of coronary atherosclerosis.</p></div>\",\"PeriodicalId\":91757,\"journal\":{\"name\":\"Journal of nutrition & intermediary metabolism\",\"volume\":\"15 \",\"pages\":\"Pages 78-83\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.jnim.2018.12.002\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of nutrition & intermediary metabolism\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2352385918300628\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of nutrition & intermediary metabolism","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352385918300628","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Assessment of the synergistic association of serum concentration of vitamin D, vitamin K and osteocalcin with coronary atherosclerosis in patients undergoing angiography
Objective
The aim of this study was to assess the association between serum concentration of vitamin D, vitamin K, and osteocalcin with coronary atherosclerosis in patients undergoing angiography.
Design
In this case-control study, 138 people who referred to Bushehr Heart Center for routine examination participated. Demographic information of the participants was registered by using a standard questionnaire. Before undergoing the angiographic processes, venous blood samples were obtained via venipuncture from the antecubital vein into gel and clot activator tubes and stored at – 80 °C until the analysis. After the angiography process was over, the normal participants entered the control group and those with coronary atherosclerosis plaque placed in the case group. Finally, serum levels of vitamin K2 and Osteocalcin were measured in the samples, by using ELISA kits and the serum level of vitamin D was measured by using HPLC.
Result
serum levels of vitamin D in the case group were significantly lower than in the control (p = 0.009) and, serum levels of osteocalcin in the case group were significantly higher than in the control (P = 0.019). There was no difference in K2 level between the two groups (P = 0.84). By separating the three factors like age, sex and T2DM in the two groups, a significant synergistic was found between the concentration of osteocalcin, vitamin D (just in <20 ng/ml) and coronary atherosclerosis (p = 0.025, p = 0.029 respectively). Further, an association was observed between vitamin D level and the severity of atherosclerosis (P = 0.041).).
Conclusion
the results of this study suggest that the increase in the level of osteocalcin and the deficiency of vitamin D is significantly associated with coronary atherosclerosis but, not with vitamin k2. Moreover, serum vitamin D concentration is associated with severity of coronary atherosclerosis.
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