阿尔茨海默病患者牙龈卟啉单胞菌感染及免疫抑制

IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Dental Hypotheses Pub Date : 2021-10-01 DOI:10.4103/denthyp.denthyp_38_21

C. Putri, E. Bachtiar

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引用次数: 2

摘要

阿尔茨海默病是最常见的神经退行性疾病之一。牙龈卟啉单胞菌是慢性牙周炎的主要病原菌，其毒力因子为牙龈痛。gingippain是一种蛋白水解酶，能够穿透血脑屏障到达大脑的认知中心。到达大脑的牙龈痛被怀疑与淀粉样斑块和神经原纤维缠结有关，这在阿尔茨海默病的形成中起着关键作用。这些细菌还可能通过降低细胞因子肿瘤生长因子(tgf - β)和干扰素(ifn - γ)以及Th17/Treg(调节性T细胞)的失衡来抑制免疫系统。此外，牙龈卟啉卟啉菌累及大脑可能引发神经炎症，导致神经元缺损，加重阿尔茨海默病。本文就牙龈卟啉卟啉与阿尔茨海默病的关系进行综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Infection of Porphyromonas gingivalis in Alzheimer’s Disease and the Suppression of Immunity

Alzheimer disease is one of the most frequent neurodegenerative diseases. Porphyromonas gingivalis is the key pathogen of chronic periodontitis, and it has a virulence factor known as gingipain. Gingipain is a proteolytic enzyme capable of penetrating the blood–brain barrier to reach the brain’s center of cognition. Gingipain that reaches the brain is suspected of having a relationship with an amyloid-beta plaque and neurofibrillary tangle, which play a critical role in the formation of Alzheimer disease. These bacteria may also suppress the immune system by reducing cytokine tumor growth factor (TGF-beta) and Interferon (IFN-gamma) and imbalance of Th17/Treg (Regulatory T cells). Besides that, the involvement of P. gingivalis in the brain may trigger neuroinflammation and lead to neuron defect and worsen Alzheimer disease. This review aims to discuss the correlation between P. gingivalis and the development of Alzheimer disease.

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来源期刊

Dental Hypotheses DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

1.00

自引率

0.00%

发文量

审稿时长

21 weeks