老年癌症患者乳腺磁共振成像（MRI）测量肿瘤大小：乳腺MRI与乳腺造影和超声的比较

IF 0.2 4区医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Iranian Journal of Radiology Pub Date : 2021-07-31 DOI:10.5812/iranjradiol.110817

J. An, J. Woo, Ji Ye Lee, B. Lee

{"title":"老年癌症患者乳腺磁共振成像（MRI）测量肿瘤大小：乳腺MRI与乳腺造影和超声的比较","authors":"J. An, J. Woo, Ji Ye Lee, B. Lee","doi":"10.5812/iranjradiol.110817","DOIUrl":null,"url":null,"abstract":"Background: With a rapid increase in the aging population around the world, there has been a surge in the number of elderly breast cancer patients. Magnetic resonance imaging (MRI) is commonly used in preoperative assessments for elderly patients. However, there has been no consensus on the accuracy of tumor size measurements by MRI. Objectives: To compare the accuracy of MRI versus conventional imaging methods, namely, mammography (MG) and ultrasound (US), in tumor size measurements in elderly patients and to determine the predictors of measurement accuracy. Patients and Methods: This study was conducted on 134 patients, aged 50 years or above (137 breasts with invasive cancer). The tumor size and T stage were assessed using MG, US, and MRI, and the results were compared with pathological findings. The tumor size differences between the imaging and pathological findings were classified as ≤ 0.5 cm or > 0.5 cm. Differences in tumor size and T stage were also analyzed based on age group (≥ 60 years vs. < 60 years), using chi-square test, Fisher’s exact test, and Cohen’s kappa coefficient. The diagnostic sensitivity, specificity, and accuracy were also measured. Besides, a multivariate logistic regression analysis was performed to evaluate the predictors of tumor size differences. Results: Tumor size differences ≤ 0.5 cm, T-stage agreement, and diagnostic performance of MRI for T stages ≥ 2 were higher in the elderly group compared to the younger group. The T-stage agreement with the histopathological results was higher on MRI compared to conventional imaging methods. For diagnosis of T stages ≥ 2, MRI showed the highest sensitivity, while US showed the highest specificity. The calcification type, dense breasts, and histological grade 3 were predictors of tumor size differences > 0.5 cm. Conclusion: The accuracy of tumor size measurements on MRI was higher in elderly patients aged ≥ 60 years. The diagnostic accuracy also increased in elderly patients with non-dense breasts and mass-type lesions. In T-stage analysis, MRI showed the highest sensitivity, while US showed the highest specificity.","PeriodicalId":50273,"journal":{"name":"Iranian Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":0.2000,"publicationDate":"2021-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Tumor Size Measurements with Breast Magnetic Resonance Imaging (MRI) in Elderly Patients with Breast Cancer: A Comparison of Breast MRI with Mammography and Ultrasound\",\"authors\":\"J. An, J. Woo, Ji Ye Lee, B. Lee\",\"doi\":\"10.5812/iranjradiol.110817\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: With a rapid increase in the aging population around the world, there has been a surge in the number of elderly breast cancer patients. Magnetic resonance imaging (MRI) is commonly used in preoperative assessments for elderly patients. However, there has been no consensus on the accuracy of tumor size measurements by MRI. Objectives: To compare the accuracy of MRI versus conventional imaging methods, namely, mammography (MG) and ultrasound (US), in tumor size measurements in elderly patients and to determine the predictors of measurement accuracy. Patients and Methods: This study was conducted on 134 patients, aged 50 years or above (137 breasts with invasive cancer). The tumor size and T stage were assessed using MG, US, and MRI, and the results were compared with pathological findings. The tumor size differences between the imaging and pathological findings were classified as ≤ 0.5 cm or > 0.5 cm. Differences in tumor size and T stage were also analyzed based on age group (≥ 60 years vs. < 60 years), using chi-square test, Fisher’s exact test, and Cohen’s kappa coefficient. The diagnostic sensitivity, specificity, and accuracy were also measured. Besides, a multivariate logistic regression analysis was performed to evaluate the predictors of tumor size differences. Results: Tumor size differences ≤ 0.5 cm, T-stage agreement, and diagnostic performance of MRI for T stages ≥ 2 were higher in the elderly group compared to the younger group. The T-stage agreement with the histopathological results was higher on MRI compared to conventional imaging methods. For diagnosis of T stages ≥ 2, MRI showed the highest sensitivity, while US showed the highest specificity. The calcification type, dense breasts, and histological grade 3 were predictors of tumor size differences > 0.5 cm. Conclusion: The accuracy of tumor size measurements on MRI was higher in elderly patients aged ≥ 60 years. The diagnostic accuracy also increased in elderly patients with non-dense breasts and mass-type lesions. In T-stage analysis, MRI showed the highest sensitivity, while US showed the highest specificity.\",\"PeriodicalId\":50273,\"journal\":{\"name\":\"Iranian Journal of Radiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2021-07-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Iranian Journal of Radiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5812/iranjradiol.110817\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Radiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5812/iranjradiol.110817","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}

引用次数: 0

摘要

背景：随着全球人口老龄化的快速增长，癌症老年患者数量激增。磁共振成像（MRI）通常用于老年患者的术前评估。然而，对于MRI测量肿瘤大小的准确性还没有达成共识。目的：比较MRI与传统成像方法，即乳腺X线摄影（MG）和超声（US）在老年患者肿瘤大小测量中的准确性，并确定测量准确性的预测因素。患者和方法：本研究对134例50岁及以上的患者（137例侵袭性癌症乳房）进行了研究。使用MG、US和MRI评估肿瘤大小和T分期，并将结果与病理结果进行比较。影像学和病理学检查结果之间的肿瘤大小差异分为≤0.5 cm或＞0.5 cm。还根据年龄组（≥60岁与<60岁），使用卡方检验、Fisher精确检验和Cohenκ系数分析了肿瘤大小和T分期的差异。还测量了诊断的敏感性、特异性和准确性。此外，还进行了多变量逻辑回归分析，以评估肿瘤大小差异的预测因素。结果：与年轻组相比，老年组肿瘤大小差异≤0.5cm、T分期一致性和T分期≥2的MRI诊断性能较高。与传统成像方法相比，MRI的T分期与组织病理学结果的一致性更高。对于T分期≥2的诊断，MRI显示最高的敏感性，而US显示最高的特异性。钙化类型、致密乳房和组织学分级3是肿瘤大小差异>0.5cm的预测因素。结论：年龄≥60岁的老年患者在MRI上测量肿瘤大小的准确性较高。在患有非致密性乳房和肿块型病变的老年患者中，诊断准确性也有所提高。在T分期分析中，MRI显示最高的敏感性，而US显示最高的特异性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Tumor Size Measurements with Breast Magnetic Resonance Imaging (MRI) in Elderly Patients with Breast Cancer: A Comparison of Breast MRI with Mammography and Ultrasound

Background: With a rapid increase in the aging population around the world, there has been a surge in the number of elderly breast cancer patients. Magnetic resonance imaging (MRI) is commonly used in preoperative assessments for elderly patients. However, there has been no consensus on the accuracy of tumor size measurements by MRI. Objectives: To compare the accuracy of MRI versus conventional imaging methods, namely, mammography (MG) and ultrasound (US), in tumor size measurements in elderly patients and to determine the predictors of measurement accuracy. Patients and Methods: This study was conducted on 134 patients, aged 50 years or above (137 breasts with invasive cancer). The tumor size and T stage were assessed using MG, US, and MRI, and the results were compared with pathological findings. The tumor size differences between the imaging and pathological findings were classified as ≤ 0.5 cm or > 0.5 cm. Differences in tumor size and T stage were also analyzed based on age group (≥ 60 years vs. < 60 years), using chi-square test, Fisher’s exact test, and Cohen’s kappa coefficient. The diagnostic sensitivity, specificity, and accuracy were also measured. Besides, a multivariate logistic regression analysis was performed to evaluate the predictors of tumor size differences. Results: Tumor size differences ≤ 0.5 cm, T-stage agreement, and diagnostic performance of MRI for T stages ≥ 2 were higher in the elderly group compared to the younger group. The T-stage agreement with the histopathological results was higher on MRI compared to conventional imaging methods. For diagnosis of T stages ≥ 2, MRI showed the highest sensitivity, while US showed the highest specificity. The calcification type, dense breasts, and histological grade 3 were predictors of tumor size differences > 0.5 cm. Conclusion: The accuracy of tumor size measurements on MRI was higher in elderly patients aged ≥ 60 years. The diagnostic accuracy also increased in elderly patients with non-dense breasts and mass-type lesions. In T-stage analysis, MRI showed the highest sensitivity, while US showed the highest specificity.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Iranian Journal of Radiology RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

0.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Iranian Journal of Radiology is the official journal of Tehran University of Medical Sciences and the Iranian Society of Radiology. It is a scientific forum dedicated primarily to the topics relevant to radiology and allied sciences of the developing countries, which have been neglected or have received little attention in the Western medical literature. This journal particularly welcomes manuscripts which deal with radiology and imaging from geographic regions wherein problems regarding economic, social, ethnic and cultural parameters affecting prevalence and course of the illness are taken into consideration. The Iranian Journal of Radiology has been launched in order to interchange information in the field of radiology and other related scientific spheres. In accordance with the objective of developing the scientific ability of the radiological population and other related scientific fields, this journal publishes research articles, evidence-based review articles, and case reports focused on regional tropics. Iranian Journal of Radiology operates in agreement with the below principles in compliance with continuous quality improvement: 1-Increasing the satisfaction of the readers, authors, staff, and co-workers. 2-Improving the scientific content and appearance of the journal. 3-Advancing the scientific validity of the journal both nationally and internationally. Such basics are accomplished only by aggregative effort and reciprocity of the radiological population and related sciences, authorities, and staff of the journal.