在螺旋接触器中制备的用于化疗药物递送的pH响应性生物聚合物基多重乳液

IF 1.1 4区工程技术 Q4 POLYMER SCIENCE

Polimery Pub Date : 2022-09-07 DOI:10.14314/polimery.2022.7.7

E. Dluska, A. Markowska-Radomska, Patryk Skowroński

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引用次数: 1

摘要

在生物聚合物中，pH响应性聚合物通过利用生理和病理状态之间的pH梯度，在药物递送系统中具有很大潜力。本文讨论了具有pH响应性生物聚合物的多种乳液在脑肿瘤治疗中的控制药物递送。考察了多重乳液的特性和流变性能、生物聚合物的吸附、ζ电位和释放过程。结果显示，与正常细胞的模拟条件相比，酸性肿瘤微环境中的药物释放率更高。

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A pH-responsive biopolymer-based multiple emulsion prepared in a helicoidal contactor for chemotherapeutics delivery

Among biopolymers, pH-responsive ones have much potential for drug delivery systems by exploiting the pH gradient between physiological and pathological states. In this paper multiple emulsions with a pH-responsive biopolymer for controlled drug delivery in brain tumor treatment were discussed. The characteristic and rheological properties of multiple emulsions, biopolymer adsorption, zeta potential, and release processes were examined. The results showed higher drug release rates in the acidic tumor microenvironment compared to the simulated conditions of normal cells.

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来源期刊

Polimery Materials Science-Polymers and Plastics

CiteScore

2.90

自引率

6.20%

发文量

审稿时长

1 months

期刊介绍： The "Polimery" journal, of international circulation, is publishing peerreviewed scientific and technical research papers covering polymer science and technology in the field of polymers, rubbers, chemical fibres and paints. The range of topics covered are raw materials, polymer synthesis, processing and applications of polymers. Apart from scientific and technical research papers the monthly includes technical and commercial information such as reports from fairs and exhibitions as well as home, world and technical news. “Polimery "- an international journal covering the following topics: polymers, rubber, chemical fibres and paints. The Journal is addressed to scientists, managers and engineering staff of universities, Polish Academy of Sciences, R&D institutions, industry, specializing in polymer chemistry, physical chemistry, technology and processing. “Polimery” publishes original, reviewed research, scientific and technology papers in the field of polymer synthesis, analysis, technology and modification, processing, properties, applications and recycling.