大鼠长期口服泛醌后唾液腺腺泡和纹管的组织病理学比较

IF 0.4 Q3 MEDICINE, GENERAL & INTERNAL
A. Abdullah, B. I. Sedeeq, Marwan Saad Azzubaidi
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引用次数: 0

摘要

摘要泛醌也被称为辅酶Q10(CoQ10),是一种维生素样内源性因子,对三磷酸腺苷(ATP)线粒体的产生至关重要。几项研究报告称,外源性补充辅酶Q10会导致唾液分泌过多,尤其是在抱怨口干的患者中。本研究的目的是通过比较辅酶Q10治疗组和对照组的腺泡和纹管直径,研究长期每日使用辅酶Q10对实验动物唾液腺的影响。将25只白化病大鼠随机分为两组;对照组包括10只大鼠,而辅酶Q10治疗组包括15只大鼠。后者每天口服300mg/kg辅酶Q10,持续6周。然后对腮腺、下颌下腺和舌下腺的样本进行解剖和组织学检查,以比较测量腺体腺泡和纹管的直径。辅酶Q10治疗组腮腺(79.8±11.2μm)和下颌下腺(81.07±13.5μm)的浆液性腺泡平均直径显著高于对照组(67.5±8.4μm和73.3±13.8μm)(P<0.05)。然而,当比较辅酶Q10治疗组和对照组的纹管直径时,差异没有统计学意义。持续和长期暴露于外源性泛醌可能导致唾液腺(即腮腺和下颌下腺)内腺泡肥大性扩张,这可能是唾液分泌过多的潜在机制。这可以被认为是一种可逆的自适应响应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Histopathological comparison of the salivary glands’ acini and striated ducts after experimental prolonged daily administration of oral ubiquinone doses in rats
Abstract Also called coenzyme Q10 (CoQ10), Ubiquinone is a vitamin-like endogenously produced factor essential for Adenosine triphosphate (ATP) mitochondrial production. Several research studies have reported that the exogenous supplementation of CoQ10 can lead to excessive salivation, especially in patients complaining of dry mouth. The objective of this study was to investigate the effect of long-term daily use of CoQ10 on the salivary glands in experimental animals by comparing the diameters of the glandular acini and striated ducts of a CoQ10-treated group and a control group. Twenty-five white albino rats were randomly divided into two groups; the control group consisted of 10 rats, while the CoQ10-treated group comprised 15 rats. The latter received daily oral treatment of 300 mg/kg CoQ10 for six weeks. Samples of the parotid, submandibular and sublingual glands were then dissected and examined histologically for comparative measurement of the diameters of the glands’ acini and striated ducts. The CoQ10 treated group had mean diameters of the serous acini for the parotid (79.8±11.2 μm) and submandibular (81.07±13.5 μm) glands that were significantly higher (P<0.05) than their diameters in the control group (67.5±8.4 μm and 73.3±13.8 μm), respectively. However, the difference was not statistically significant when comparing the diameters of striated ducts of the CoQ10-treated group and the control group. Continuous and prolonged exposure to exogenous ubiquinone may cause hypertrophic dilation of the acini within the salivary glands, namely the parotid and submandibular glands, which might be the underlying mechanism for excessive salivation. This can be considered a reversible adaptive response.
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来源期刊
Current Issues in Pharmacy and Medical Sciences
Current Issues in Pharmacy and Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
0.80
自引率
0.00%
发文量
28
审稿时长
16 weeks
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