基于ICP-MS的金属组学方法论：单颗粒分析、单细胞分析和空间金属组学

IF 3.4 2区化学 Q1 SPECTROSCOPY

Atomic Spectroscopy Pub Date : 2022-06-30 DOI:10.46770/as.2022.108

Mingli Chen, Meng Wang

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引用次数: 9

摘要

作为一门新兴的交叉学科，金属组学旨在从系统的角度整合生物系统中金属及类金属的相关研究领域。电感耦合等离子体质谱(ICP-MS)被认为是金属组学研究中最通用的工具之一。这篇综述介绍了ICP-MS的简要概述，并描述了ICP-MS仪器的最新进展。然后，讨论了基于icp - ms的方法和应用，重点讨论了单颗粒分析、单细胞分析和空间金属组学。随着仪器和方法的快速发展，基于icp - ms的方法将进一步发展，并在金属学研究中发挥主导作用。

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ICP-MS-Based Methodology In Metallomics: Towards Single Particle Analysis, Single Cell Analysis, And Spatial Metallomics

: As an emerging interdisciplinary science, metallomics aims to integrate research fields related to metals and metalloids in biological systems from a systematic perspective. Inductively coupled plasma mass spectrometry (ICP-MS) is considered one of the most versatile tools for metallomics research. This review presents a brief overview of ICP-MS and describes recent advances in ICP-MS instrumentation. Then, ICP-MS-based methods and applications are discussed, focusing on single particle analysis, single cell analysis, and spatial metallomics. With the rapid developments in instrumentation and methodology, ICP-MS-based methodologies will evolve further and play a dominant role in metallomics research.

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来源期刊

Atomic Spectroscopy 物理-光谱学

CiteScore

5.30

自引率

14.70%

发文量

审稿时长

4.5 months

期刊介绍： The ATOMIC SPECTROSCOPY is a peer-reviewed international journal started in 1962 by Dr. Walter Slavin and now is published by Atomic Spectroscopy Press Limited (ASPL). It is intended for the rapid publication of both original articles and review articles in the fields of AAS, AFS, ICP-OES, ICP-MS, GD-MS, TIMS, SIMS, AMS, LIBS, XRF and related techniques. Manuscripts dealing with (i) instrumentation & fundamentals, (ii) methodology development & applications, and (iii) standard reference materials (SRMs) development can be submitted for publication.