调强放疗局部晚期头颈癌患者的腮腺剂量体积直方图与口干性放疗肿瘤组评分相关吗?

S. Goel, R. Bhutani, V. Bansal, R. Goel
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引用次数: 0

摘要

摘要简介口干症是头颈部放射治疗的一种常见并发症,主观评价效果最好。本研究旨在评估调强放射治疗(IMRT)保留腮腺对局部晚期头颈部癌患者主观口干评分的影响。研究对象和方法这是一项在门诊进行的前瞻性纵向研究。根据ICRU 62(国际放射单位和测量委员会报告62),共有43名头颈癌患者计划接受IMRT。同侧腮腺和对侧腮腺的约束分别为35 Gy和25 Gy。治疗方案的剂量分别为100、67、50和33%腮腺体积。使用Amosson问卷对患者进行主观评估,并根据Eisbruch的口干性放射治疗肿瘤组评分进行评分。绘制剂量-体积直方图(DVH),并与术后1、3、6、9和12个月的口干程度相关。统计学分析采用SPSS version 16,卡方检验,单因素方差分析。结果放疗后平均放射剂量、腮腺体积和口干程度无统计学意义。在3 - 6个月(p = 0.0)、3 - 9个月(p = 0.020)、6 - 9个月(p = 0.009)、6 - 12个月(p = 0.05)和9 - 12个月(p = 0.00)期间,口干症的等级有统计学意义上的改善。在9个月时,评分恢复。结论腮腺DVH与口干症分级无直接相关性,但分级恢复在9个月时有统计学意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Does Dose Volume Histogram of Parotid Glands Correlate with Xerostomia Radiation Therapy Oncology Group Scores in Locoregionally Advanced Head and Neck Cancer Patients Treated with Intensity-Modulated Radiation Therapy?
Abstract Introduction Xerostomia is an imminent complication of head and neck radiotherapy best assessed subjectively. This study aimed to evaluate the effects of sparing parotid glands with intensity-modulated radiation therapy (IMRT) on subjective xerostomia scores in patients with locoregionally advanced head and neck cancer. Subjects and Methods This is a prospective longitudinal study conducted in an outpatient department setting. A total of 43 patients with head and neck cancer were planned with IMRT as per the ICRU 62 (International Commission on Radiation Units and Measurement Report 62). The constraints to ipsilateral and contralateral parotid glands were 35 and 25 Gy, respectively. Treatment plan was assessed for doses to 100, 67, 50, and 33% volume of individual parotid glands. Patients were subjectively assessed using the Amosson’s Questionnaire and graded as per Eisbruch’s xerostomia Radiation Therapy Oncology Group scores. Dose volume histogram (DVH) was plotted and correlated with grades of xerostomia postradiation at 1, 3, 6, 9 and 12 months follow-ups. Statistical analysis was performed suing SPSS version 16, chi-square test, and one-way analysis of variance test. Results No statistically significant correlation between mean dose of radiation, volume of the parotid glands, and grades of xerostomia was noted postradiation. A statistically significant improvement in grades of xerostomia between 3 and 6 months (p = 0.0), 3 and 9 months (p = 0.020), 6 and 9 months (p = 0.009), 6 and 12 months (p = 0.05), and 9 and 12 months (p = 0.00) was noted. Recovery in grades was noted at 9 months. Conclusion There is no statistically significant direct correlation between DVH of the parotid glands and grades of xerostomia, although recovery in grades was statistically significant at 9 months.
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