区域抗逆转录病毒治疗计划中尼日利亚成年人的病毒抑制：一项横断面描述性研究

艾滋病(英文) Pub Date : 2021-03-15 DOI:10.4236/WJA.2021.111001

E. Isaac, A. Ajani, A. J. Difa, J. Aremu, Oyeniyi Christianah Oluwaseun, Muhammad Hassan

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引用次数: 1

摘要

背景:尼日利亚成人抗逆转录病毒治疗方案于2002年启动。经过该国多年的抗逆转录病毒治疗，2016年启动了扩大病毒载量检测的国家实施计划。病毒载量估计是抗逆转录病毒治疗反应最重要的指标。材料和方法:2017年12月至2019年12月，在贡贝联邦教学医院聚合酶链反应实验室，对尼日利亚4个州接受高活性抗逆转录病毒治疗的9450名艾滋病毒感染者的病毒载量血液样本进行了HIV RNA分析。结果:男性2577/9450例(27.3%)，女性6873例(72.7%)。26 - 45岁的成年人占69.5%(6572)。96.3%(9098)的患者进行常规病毒载量检测。AZT/3TC/NVP占52.5%(4962例);TDF/3TC/EFV占46.3%(4375)。48.3%(4568/9450)成人接受HAART治疗1 - 5年;7.4%(699)为6个月，但10年。6.5%(612)成人在病毒载量请求前CD4≥1000/μL;500 ~ 999/μL占38.6% (3651);350 ~ 499 μL, 23.2% (2195); 1000 μL, 22.8% (587/2577); 23.0% (1580/6873);在19 - 25岁的成年人中，28.4%(211/743)的病毒载量为1000 c/ml;23.5% (1544/6572);20.0% (294/1473);26 ~ 45岁17.8%(93/523)，46 ~ 55岁18.0% (25/139);56 - 65岁和55 - 65岁的成年人在HAART治疗6个月- 1年的26.0%(182/699)和接受HAART治疗1 - 5年后的21.3%(975/4568)的病毒载量>为1000 c/ml (p值为1000 c/ml)。24.9%(885/3551)和19.8%(125/632)的成人在接受HAART治疗6 ~ 10年和10年后的病毒载量分别为>0 000 c/ml和>0 000 c/ml。(p值< 0.001)结论:在我们的研究中，77%的病毒抑制率很高，但低于WHO阈值90%。尼日利亚的抗逆转录病毒治疗方案需要加强。

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Viral Suppression in Adult Nigerians in a Regional Antiretroviral Therapy Programme: A Cross Sectional Descriptive Study

Background: The adult ART (antiretroviral therapy) programme started in Nigeria in 2002. After many years of ART in the country, the National implementation plan for the scale up of viral load testing was launched in 2016. Viral load estimation is the most important indicator of ART response. Aim: To describe viral suppression in adults on the HIV ART programme Material & methods: Viral load blood samples of 9450 adults on highly active antiretroviral therapy living with HIV from 4 states within Nigeria were analyzed for HIV RNA in Polymerase Chain Reaction laboratory of the Federal Teaching Hospital, Gombe between December 2017 and December 2019. Results: Males were 2577/9450 (27.3%) and 6873 (72.7%) females. Adults aged 26 - 45 years constituted 69.5% (6572). Viral load test was primarily routine in 96.3% (9098). ART was AZT/3TC/NVP in 52.5% (4962); TDF/3TC/EFV in 46.3% (4375). 48.3% (4568/9450) adults had received HAART for 1 - 5 years; 7.4% (699) for 6 months but 10 years. The most recent CD4 count before viral load request was ≥1000/μL in 6.5% (612) of adults; 500 - 999/μL in 38.6% (3651); 350 - 499 μL in 23.2% (2195) and 1000 c/ml in 22.8% (587/2577) males and 23.0% (1580/6873) females. Of adults aged 19 - 25 years, 28.4% (211/743) had viral load >1000 c/ml; 23.5% (1544/6572); 20.0% (294/1473); 17.8% (93/523) and 18.0% (25/139) aged 26 - 45 years, 46 - 55 years; 56 - 65 years and >65 years also had viral load >1000 c/ml (p value 1000 c/ml in 26.0% (182/699) of adults on HAART for 6 months - 1 year and 21.3% (975/4568) after receiving HAART for 1 - 5 years. 24.9% (885/3551) and 19.8% (125/632) adults had viral load > 1000 c/ml after receiving HAART for 6 - 10 and >10 years respectively. (p value < 0.001) Conclusion: Over all viral suppression of 77% in our study is high but fell below the WHO threshold of 90%. ART programme in Nigeria requires strengthening.

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艾滋病(英文)

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282