蒙特利尔认知评估（MOCA）与简易精神状态检查（MMSE）对苯妥英单药治疗癫痫患者同型半胱氨酸与认知状态关系的比较

Pub Date : 2018-06-08 DOI:10.1080/21507686.2018.1483411

Rajendran Natham, P. Amirthalingam, Ganesvaran Arunachalam

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引用次数: 1

摘要

迷你精神状态检查(MMSE)已被用作检测抗癫痫药物治疗患者认知功能障碍的工具，但未能检测出这些患者的轻度认知功能障碍。研究报告蒙特利尔认知评估(MOCA)在检测脑卒中、帕金森病、心血管疾病和癫痫患者的认知状态方面比MMSE更敏感。同型半胱氨酸与癫痫患者认知障碍的调节有关，但由于大多数研究采用MMSE，因此无法明确证实。为了探讨同型半胱氨酸与认知状态的关系，本研究采用MOCA与MMSE对苯妥英单药治疗的癫痫患者进行比较。我们的研究结果表明，MOCA在证明同型半胱氨酸与癫痫患者认知功能障碍之间的关系方面比MMSE更敏感。

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Comparison of Montreal Cognitive Assessment (MOCA) with Mini Mental State Examination (MMSE) on association between homocysteine and cognitive status in epilepsy patients with phenytoin monotherapy

ABSTRACT Mini Mental State Examination (MMSE) has been used as a tool to detect cognitive impairment in patients treated with antiepileptic drugs, however fail to detect mild cognitive impairment in these patients. Studies report Montreal Cognitive Assessment (MOCA) is more sensitive than MMSE in detecting cognitive status in patients with stroke, parkinsonism, cardiovascular disease and epilepsy. Homocysteine has been implicated in the modulation of cognitive impairment in epilepsy but could not be established clearly as most studies followed MMSE. To investigate the relationship between homocysteine and cognitive status the present study employed MOCA in comparison with MMSE in epilepsy population with phenytoin monotherapy. Our findings suggest MOCA is more sensitive than MMSE in demonstrating the relationship between homocysteine and cognitive impairment in epilepsy.

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