AMP活化蛋白激酶在缺血性心脏病中的作用

国际麻醉学与复苏杂志 Pub Date : 2019-12-15 DOI:10.3760/CMA.J.ISSN.1673-4378.2019.12.019

Long Yang

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引用次数: 0

摘要

有效预防和治疗围手术期心肌缺血再灌注损伤是多学科亟待解决的重要问题。优化缺血心肌的能量代谢对减轻心肌缺血/再灌注损伤至关重要。已经证实，AMP活化蛋白激酶（AMPK）是能量代谢的重要枢纽，可以通过增加葡萄糖摄取、促进自噬和抑制细胞凋亡来减少缺血性心肌损伤。本文综述了AMPK对缺血性心脏病的保护作用及其机制，为寻求以AMPK为靶点的防治心肌缺血/再灌注损伤的策略提供了理论依据。关键词：AMP活化蛋白激酶；心肌缺血；能量代谢

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The role of AMP-activated protein kinase in ischemic heart disease

Effective prevention and treatment of perioperative myocardial ischemia-reperfusion injury is an important problem to be urgently solved by multiple disciplines. Optimizing the energy metabolism of ischemic myocardium is essential to alleviate myocardial ischemia/reperfusion injury. It has been confirmed that AMP-activated protein kinase (AMPK) is an important hub of energy metabolism, and can reduce ischemic myocardial injury by increasing glucose uptake, promoting autophagy and inhibiting apoptosis. This paper summarizes the protective effect and mechanism of AMPK in ischemic heart disease, and provides theoretical evidence for seeking the strategy of preventing and treating myocardial ischemia/reperfusion injury with AMPK as the target. Key words: AMP-activated protein kinase; Myocardial ischemia; Energy metabolism

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国际麻醉学与复苏杂志

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