重症监护室侵袭性肺曲霉病的诊断:我们应该关注什么以及如何做得更好

Hui Shen, Wentao Bao, Yuetian Yu
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引用次数: 2

摘要

侵袭性肺曲霉病(IPA)在重症监护病房(ICU)不再是一种罕见的疾病,这是由于越来越多的免疫功能低下的宿主入院,侵入性治疗程序的应用和广谱抗生素的广泛使用。与粒细胞缺乏症不同,ICU患者IPA的症状和体征是微妙的或非特异性的,无法与细菌性肺炎甚至非传染性疾病区分开来。因此,准确诊断IPA是非常有挑战性的。在这篇综述中,我们将浏览目前可用的IPA诊断测试以及它们如何应用于ICU人群。特别关注的是非文化基础的测试,以及对未来的展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diagnosis of invasive pulmonary aspergillosis in the intensive care unit: what we should concern and how to do better
Invasive pulmonary aspergillosis (IPA) is no longer a rare disease in the intensive care unit (ICU) on account of the increased number of immunocompromised hosts admitted, the application of invasive treatment procedures and the widespread use of broad-spectrum antibiotics. Different from those with agranulocytosis, symptoms and signs of IPA in ICU patients are subtle or non-specific which are unable to be distinguished from those with bacterial pneumonia or even with noninfectious diseases. Thus, accurately diagnosing of IPA is quite challenging. In this review, we will navigate through the IPA diagnostic tests currently available and how they apply to ICU population. Special attention is paid to the non-culture- based tests as well as have a look into what the future holds.
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