一种有效、快速、简便、同时测定血透炎症患者实验室配制混合物中卡托普利和替米沙坦含量的方法

Q3 Pharmacology, Toxicology and Pharmaceutics

International Journal of Pharmaceutical Quality Assurance Pub Date : 2023-06-25 DOI:10.25258/ijpqa.14.2.02

Hiren Rana, Richa A. Dayaramani, Nikunj Patadiya

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引用次数: 0

摘要

卡托普利和替米沙坦是广泛使用的抗高血压药物，它们的固定剂量组合正在进行IV期试验。在本研究中，成功开发了分光光度法和RP-HPLC方法，并按照标准规定进行了验证。在紫外分光光度法中，用联立方程法测定实验室制备的合成混合物中卡托普利和替米沙坦的浓度。卡托普利和替米沙坦的线性分别为8至40μg/mL和5至25μg/mL。发现两种药物的R2（相关系数）值均为0.999。浓度的%测定。卡托普利和替米沙坦在合成混合物中的含量在可接受的范围内。在RP-HPLC法中，卡托普利和替米沙坦的%测定分别为100.05%和100.16%，%RSD值分别为0.34和0.58。所提出的紫外-高效液相色谱法同时测定卡托普利和替米沙坦的含量，在定性鉴别和定量测定方面具有潜在的应用前景。

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A Validated, Fast and Simple, Simultaneous Determination of Captopril and Telmisartan in Laboratory Prepared Mixture for Use in Haemodialysis Patients Suffering from Inflammation

Captopril and telmisartan are widely used anti-hypertensive drugs, and their fixed dose combination is under phase IV trials. In the present study, spectrophotometry and RP-HPLC methods were successfully developed and validated per standard regulations. In UV spectrophotometry method concentrations of captopril and telmisartan in a synthetic mixture prepared in the laboratory were determined using the simultaneous equation method. The linearity was found 8 to 40 μg/mL for captopril and 5 to 25 μg/mL for telmisartan. The R2 (Coefficient of Correlation) value was found to be 0.999 for both drugs. The %assays of the conc. of captopril and telmisartan in synthetic mixture were found in an acceptable range. In the RP-HPLC method %assay was found to be 100.05 and 100.16% with %RSD value of 0.34 and 0.58 for captopril and telmisartan, respectively. The proposed UV and RP-HPLC method simultaneous estimation of captopril and telmisartan has potential application for qualitative identification as well as quantitative determination.

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来源期刊

International Journal of Pharmaceutical Quality Assurance Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE is a quarterly international journal publishing the finest peer-reviewed research in the field of Pharmaceutical Quality Assurance and Pharmaceutical Analysis on the basis of its originality, importance, disciplinary interest, timeliness, accessibility, elegance, and surprising conclusions. IJPQA also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.