与SARS-CoV-2感染相关的儿童多系统炎症综合征(MIS-C)的心脏表现

IF 0.5 Q4 PEDIATRICS
A. Ghodsi, Elnaz Mahmoudabadi, S. Ghahremani, A. Malek
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引用次数: 4

摘要

背景:儿童多系统炎症综合征(MIS-C)是严重急性呼吸综合征冠状病毒2(SARS-CoV-2)大流行新冠肺炎传播后出现的一种疾病。本研究旨在描述被诊断为MIS-C的儿童的心脏表现。证据获取:这项叙述性审查是通过搜索PubMed、Scopus和Google Scholar数据库进行的,以审查截至2020年9月30日的MIS-C心脏表现。提取人口统计学特征、既往病史、临床体征和症状、心脏受累和新冠肺炎确诊类型。结果:在许多儿童中,MIS-C似乎是新冠肺炎感染的感染后并发症。这种综合征影响多个器官,并有各种类似川崎病的临床表现。患者经常表现为持续发烧、肾损伤、胃肠道(GI)问题、神经症状、粘膜变化、结膜炎和心脏受累。患有MIS的儿童更容易出现低血压、休克和心脏功能障碍,而不是冠状动脉异常和心律失常。MIS患儿需要密切观察;一些人需要住院治疗,还有一些人可能需要儿科重症监护室(PICU)入院治疗。目前的治疗包括抗凝血剂、静脉注射免疫球蛋白和抗炎药。结论:作为一种与严重急性呼吸系统综合征冠状病毒2型感染相关的新型综合征,MIS-C具有潜在的致死性。心脏表现,包括冠状动脉和心肌受累,是常见的,应该仔细识别。在及时诊断和适当治疗的情况下,大多数儿童都会存活下来,但疾病的结果尚不清楚,因此需要长期随访。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cardiac Manifestations of Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with SARS-CoV-2 Infection
Context: Multisystem inflammatory syndrome in children (MIS-C) is an emerging condition after the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, termed COVID-19. This study aimed to describe the cardiac manifestations of children diagnosed with MIS-C. Evidence Acquisition: This narrative review was conducted by searching the PubMed, Scopus, and Google Scholar databases to review MIS-C cardiac manifestations up to September 30, 2020. The demographic features, past medical history, clinical signs and symptoms, cardiac involvement, and the type of COVID-19 diagnosis confirmation were extracted. Results: In many children, MIS-C seems to be a post-infectious complication of the COVID-19 infection. This syndrome affects multiple organs and has various clinical manifestations mimicking Kawasaki disease. Patients frequently present with persistent fever, kidney injury, gastrointestinal (GI) problems, neurologic symptoms, mucosal changes, conjunctivitis, and cardiac involvement. Children with MIS are more likely to present with hypotension, shock, and cardiac dysfunction, rather than coronary artery abnormalities and arrhythmia. Children with MIS need close observation; some need to be hospitalized, and a few may need a Pediatric Intensive Care Unit (PICU) admission. Treatment currently includes anticoagulants, IV immunoglobulin, and anti-inflammatory drugs. Conclusions: As a novel syndrome associated with SARS-CoV-2 infection, MIS-C is potentially lethal. Cardiac manifestations, including coronary and myocardial involvement, are common and should be carefully identified. With prompt diagnosis and proper treatment, most children will survive, but the outcomes of the disease are unknown, so long-term follow-ups are required.
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来源期刊
CiteScore
1.80
自引率
14.30%
发文量
22
期刊介绍: Archives Of Pediatric Infectious Disease is a clinical journal which is informative to all practitioners like pediatric infectious disease specialists and internists. This authoritative clinical journal was founded by Professor Abdollah Karimi in 2012. The Journal context is devoted to the particular compilation of the latest worldwide and interdisciplinary approach and findings including original manuscripts, meta-analyses and reviews, health economic papers, debates and consensus statements of clinical relevance to pediatric disease field, especially infectious diseases. In addition, consensus evidential reports not only highlight the new observations, original research and results accompanied by innovative treatments and all the other relevant topics but also include highlighting disease mechanisms or important clinical observations and letters on articles published in the journal.
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