了解胰腺癌干细胞及其在癌变中的作用:综述。

Q1 Biochemistry, Genetics and Molecular Biology
Vikram Sumbly, Ian Landry
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引用次数: 5

摘要

目的综述胰腺癌的发病机制,进一步了解异常干细胞在胰腺癌发生发展中的作用。胰腺癌是一种高度致命的疾病,由胰腺外分泌腺或神经内分泌腺不受控制的增殖引起。人们认为,胰腺癌起源于一小部分异常肿瘤干细胞(CSCs),它们促进肿瘤发生、肿瘤转移和治疗抵抗。CD133、CXCR4、DCLK1、c-MET、ABCG2和Lgr5等分子标记是检测和观察胰腺癌干细胞(PCSCs)行为的常规方法。方法采用相关关键词在PubMed、谷歌Scholar、Scopus、Clinicaltrials.gov和Web of Science进行综合检索。选择PCSCs与胰腺癌发病机制、生物化学和临床试验相关的文章。结论虽然对胰腺癌的确切病因知之甚少,但PCSCs似乎在胰腺癌发生中起着重要作用。突变的生化级联包括Sonic Hedgehog、K-RAS-JNK、DLL4/Notch和Nodal/Activin。一些临床试验正在试图确定移植造血干细胞或外周干细胞是否可用于治疗这种侵袭性肿瘤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Understanding pancreatic cancer stem cells and their role in carcinogenesis: a narrative review.
Objective The purpose of this review article is to describe the pathogenesis of pancreatic cancer and to better understand the role of abnormal stem cells in the development of pancreatic cancer. Background Pancreatic cancer is a highly fatal disease that is caused by the uncontrolled proliferation of pancreatic exocrine or neuroendocrine glands. It is believed that pancreatic cancers arise from a small population of abnormal cancer stem cells (CSCs) that promote tumorigenesis, tumor metastasis and therapeutic resistance. The molecular markers CD133, CXCR4, DCLK1, c-MET, ABCG2 and Lgr5 are routinely used to detected and observe the behaviours of pancreatic cancer stem cells (PCSCs). Methods A comprehensive search was performed on PubMed, Google Scholar, Scopus, Clinicaltrials.gov and Web of Science using related keywords. Articles focusing on PCSCs and pancreatic cancer pathogenesis, biochemistry and clinical trials were selected. Conclusions Although very little is known about the exact cause of pancreatic cancer, PCSCs seem to play an important role in carcinogenesis. Mutated biochemical cascades include Sonic Hedgehog, K-RAS-JNK, DLL4/Notch and Nodal/Activin. Several clinical trials are trying to determine if the transplantation of hematopoietic stem cell or peripheral stem cells could be useful for the treatment of such an aggressive tumor.
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来源期刊
Stem cell investigation
Stem cell investigation Biochemistry, Genetics and Molecular Biology-Developmental Biology
CiteScore
5.80
自引率
0.00%
发文量
9
期刊介绍: The Stem Cell Investigation (SCI; Stem Cell Investig; Online ISSN: 2313-0792) is a free access, peer-reviewed online journal covering basic, translational, and clinical research on all aspects of stem cells. It publishes original research articles and reviews on embryonic stem cells, induced pluripotent stem cells, adult tissue-specific stem/progenitor cells, cancer stem like cells, stem cell niche, stem cell technology, stem cell based drug discovery, and regenerative medicine. Stem Cell Investigation is indexed in PubMed/PMC since April, 2016.
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