黑眼苏珊藤(Thunbergia alata):哥伦比亚一种入侵植物的化学和抗真菌潜力评估

Q2 Multidisciplinary
Miguel Ángel Vanegas Romero, Luis Carlos Chitiva, C. P. Bravo-Chaucanés, Andrea Ximena Hernández, C. Parra-Giraldo, G. M. Costa
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引用次数: 0

摘要

Thunbergia alata(黑眼苏珊)是一种来自东非的植物,生长在包括哥伦比亚在内的世界热带地区,在一些国家被认为是入侵物种。尽管当地社区使用它来治疗包括疟疾在内的几种疾病,但很少有关于阿拉塔的生物和化学研究。因此,本研究旨在探讨草菇粗乙醇茎叶提取物的化学组成和体外抗念珠菌活性。这是通过植物化学分析和色谱分析(HPTLC、UPLC-DAD和LC-MS)实现的。采用两倍连续微量稀释法测定对所选念珠菌菌株的最低抑菌浓度(MIC)。结果表明,虽然芦丁和绿原酸分别是草叶提取物和草叶提取物的主要成分,但草叶提取物中存在皂苷、萜烯和黄酮类化合物。关于生物测定,草叶提取物显示出中等的抗真菌活性,对白色念珠菌和金黄色念珠菌菌株的MIC值在5:00 mg mL-1和1:25 mg mL-1之间。结果表明,T.alata提取物,包括它们的一些主要鉴定化合物,对两种重要微生物具有良好的抗真菌性能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Black-eyed Susan vine (Thunbergia alata): chemical and antifungal potential evaluation of an invasive plant species in Colombia
Thunbergia alata (Black-eyed Susan) is a plant species from East Africa and grows in tropical regions worldwide, including Colombia, being considered an invasive species in some countries. Even though it is used by local communities to treat several illnesses, including malaria, there are few biological and chemical studies on T. alata. Therefore, this study aimed to explore the chemical composition and in vitro antimycotic (against Candida strains) activity of T. alata crude ethanolic stem and leaf extracts. This was achieved via phytochemical analyses and chromatographic profiling (HPTLC, UPLC-DAD, and LC-MS). A two-fold serial microdilution method was used to determine the minimum inhibitory concentration (MIC) against selected Candida strains. Results showed the presence of saponins, terpenes, and flavonoids in the T. alata crude ethanolic stem and leaf extracts, although rutin and chlorogenic acid were the main components of stem and leaf extracts, respectively. Concerning biological assays, T. alata leaf extracts demonstrated moderate antimycotic activity, with MIC values between 5:00 mg mL-1 and 1:25 mg mL-1 against C. albicans and C. auris strains. The results indicate that T. alata extracts, including some of their major identified compounds, possess promising antifungal properties against two significant microorganisms.
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来源期刊
Universitas Scientiarum
Universitas Scientiarum Multidisciplinary-Multidisciplinary
CiteScore
1.20
自引率
0.00%
发文量
9
审稿时长
15 weeks
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