一步法合成对人胰腺癌症细胞具有细胞毒性的新Betulic酸衍生物

Q2 Pharmacology, Toxicology and Pharmaceutics

Current Bioactive Compounds Pub Date : 2023-07-05 DOI:10.2174/1573407219666230705160027

Muhammad Ali, G. Ahmed, Huma Rasheed, S. Kainat, Itrat Fatima, Azra Akbar

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引用次数: 0

摘要

设计并有效地实现了一锅法合成新的具有重要生物学意义的白桦酸衍生物。利用白桦酸的羧基和羟基部分，形成了一锅法合成某些目标化合物的方法。通过羧基官能团与多种烷基化剂的酯化反应，实现了一锅法合成新型白桦酸衍生物3-9的中高收率。用光谱技术对其进行了充分表征。对合成的新白桦酸衍生物对人胰腺癌细胞的细胞毒作用进行了筛选。

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One-pot Synthesis of Some New Betulinic Acid Derivatives with Cytotoxicity Against Human Pancreatic Cancer Cells

One-pot synthesis of new and biologically important betulinic acid derivatives has been designed and efficiently achieved in this work. The utilization of the carboxylic and hydroxyl moieties of betulinic acid has resulted in the development of a one-pot strategy towards the synthesis of some target compounds. One-pot synthesis of new betulinic acid derivatives 3-9 has been achieved in moderate to high yields by way of esterification of the carboxylic functionality with a variety of alkylating agents. These were fully characterized by spectroscopic techniques. The synthesized new derivatives of betulinic acid were screened for their cytotoxic effect against human pancreatic cancer cells.

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来源期刊

Current Bioactive Compounds Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

1.90

自引率

0.00%

发文量

112

期刊介绍： The journal aims to provide comprehensive review articles on new bioactive compounds with proven activities in various biological screenings and pharmacological models with a special emphasis on stereoeselective synthesis. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia. The journal should prove to be essential reading for pharmacologists, natural product chemists and medicinal chemists who wish to be kept informed and up-to-date with the most important developments on new bioactive compounds of natural or synthetic origin, including their stereoeselective synthesis.