重要药用二氢嘧啶酮杂环支架的化学研究

IF 1.9 4区化学 Q2 CHEMISTRY, ORGANIC

Mini-reviews in Organic Chemistry Pub Date : 2022-12-01 DOI:10.2174/1570193x20666221201113822

Anjaneyulu Bendi, Versha, Ravi Rana

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引用次数: 0

摘要

在药物化学中，基于二氢嘧啶酮的杂环支架由于其巨大的药理和生物活性而获得了突出的地位。创新药物的发现和开发可以对抗多种疾病，这证明了这些化合物的实用性。本研究总结了截至2022年可用于合成各种基于二氢嘧啶酮的杂环支架的各种方法及其有益的药用特性。

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Chemistry of Medicinally important Dihydropyrimidinone-based Heterocycle Scaffolds

In medicinal chemistry, Dihydropyrimidinone-based heterocycle scaffolds have attained a prominent place due to their enormous pharmacological and biological activities. The discovery and development of innovative drugs to combat a wide range of diseases exemplify the utility of these compounds. The present study summarizes the variety of methods available to synthesize various dihydropyrimidinone-based heterocycle scaffolds and their beneficial medicinal properties with the available literature until 2022.

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来源期刊

Mini-reviews in Organic Chemistry 化学-有机化学

CiteScore

4.50

自引率

4.30%

发文量

116

审稿时长

>12 weeks

期刊介绍： Mini-Reviews in Organic Chemistry is a peer reviewed journal which publishes original reviews on all areas of organic chemistry including organic synthesis, bioorganic and medicinal chemistry, natural product chemistry, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly, without any charges. The journal encourages submission of reviews on emerging fields of organic chemistry including: Bioorganic Chemistry Carbohydrate Chemistry Chemical Biology Chemical Process Research Computational Organic Chemistry Development of Synthetic Methodologies Functional Organic Materials Heterocyclic Chemistry Macromolecular Chemistry Natural Products Isolation And Synthesis New Synthetic Methodology Organic Reactions Organocatalysis Organometallic Chemistry Theoretical Organic Chemistry Polymer Chemistry Stereochemistry Structural Investigations Supramolecular Chemistry