维生素C对Wi-Fi (2.45 GHz电磁辐射)大鼠肝脏病理的改善作用

Q4 Health Professions

Iranian Journal of Radiation Research Pub Date : 2020-07-10 DOI:10.18869/ACADPUB.IJRR.18.3.405

O. Ozmen, O. Kavrik

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引用次数: 2

摘要

背景：本研究的目的是研究2.45GHz无线局域网电磁辐射（EMR）对大鼠肝脏的损伤和维生素C（Vit C）的保护作用。材料和方法：将18只SpragueDawley雌性大鼠随机分为三组，每组6只。对照组、EMR组（EMR，1小时/天，持续30天）和EMR+Vit C组（EMR:1小时/天持续30天，Vit C，250 mg/kg/天）。研究结束时，采集血液和肝组织样本进行实验室检查。结果：与对照组相比，EMR组血清天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）水平升高。EMR组大鼠的肝脏组织学表现为严重充血、轻度变性和脂质沉积。EMR组肝细胞中Caspase-3、低氧诱导因子-1（HIF-1）和HIF-2的免疫表达增加，SIRT-1的表达显著降低。维生素C治疗改善了生化和病理结果。结论：2.45GHz（Wi-Fi）电磁辐射可引起大鼠肝损伤，但维生素C有改善作用。

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Ameliorative effects of vitamin C against hepatic pathology related to Wi-Fi (2.45 GHz electromagnetic radiation) in rats

Background: The aim of this study was to investigate hepatic lesions induced by the 2.45 GHz electromagnetic radiation (EMR) of Wi-Fi and the protective effects of Vitamin C (Vit C) in rats. Materials and Methods: Eighteen SpragueDawley female rats were randomly distributed into three groups, each containing six rats. The groups were Control, EMR (EMR, 1 h/day for 30 days) and EMR + Vit C (EMR, 1 h/day for 30 days and Vit C, 250 mg/kg/daily). At the end of the study, blood and liver tissue samples were collected for laboratory examinations. Results: Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were increased in the EMR group compared with the control group. Liver histology of rats in the EMR group revealed severe hyperemia, slight degeneration, and lipidosis. Caspase-3, hypoxiainducible factor-1 (HIF-1), and HIF-2 immunoexpression was increased, and Sirtuin-1 (SIRT-1) expression was markedly decreased in hepatocytes in the EMR group. Vit C treatment ameliorated both biochemical and pathological findings. Conclusion: The results of this study showed that 2.45 GHz (Wi-Fi) EMR can cause liver damage in rats, but Vit C has an ameliorative effect.

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来源期刊

Iranian Journal of Radiation Research RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

0.67

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Iranian Journal of Radiation Research (IJRR) publishes original scientific research and clinical investigations related to radiation oncology, radiation biology, and Medical and health physics. The clinical studies submitted for publication include experimental studies of combined modality treatment, especially chemoradiotherapy approaches, and relevant innovations in hyperthermia, brachytherapy, high LET irradiation, nuclear medicine, dosimetry, tumor imaging, radiation treatment planning, radiosensitizers, and radioprotectors. All manuscripts must pass stringent peer-review and only papers that are rated of high scientific quality are accepted.