药物引起的代谢性酸中毒

Q4 Medicine

Adverse Drug Reaction Bulletin Pub Date : 2017-06-01 DOI:10.1097/FAD.0000000000000025

C. Holt, Andrew W. Hitchings

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引用次数: 3

摘要

代谢性酸中毒的药物原因多种多样，其机制也多种多样。一般来说，它们可以引起阴离子间隙正常的代谢性酸中毒（如药物诱导的肾小管酸中毒）或阴离子间隙升高（如药物诱发的乳酸酸中毒或焦谷氨酸酸中毒）。这篇综述描述了在治疗过程中可能导致或有助于代谢性酸中毒的药物，发生这种情况的机制，以及如何在实践中识别它们。

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Drug-induced metabolic acidosis

Summary Drug causes of metabolic acidosis are numerous and their mechanisms are diverse. Broadly, they can cause metabolic acidosis with either a normal anion gap (e.g. drug-induced renal tubular acidosis) or an elevated anion gap (e.g. drug-induced lactic acidosis or pyroglutamic acidosis). This review describes the drugs that can cause or contribute to metabolic acidosis during therapeutic use, the mechanisms by which this occurs, and how they may be identified in practice.

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来源期刊

Adverse Drug Reaction Bulletin Medicine-Pharmacology (medical)

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： For over 40 years, Adverse Drug Reaction Bulletin has provided comprehensive coverage in the field of adverse drug reactions. Each issue contains an invited article on a topic of current interest, dealing with specific conditions from drug-induced lung disorders to drug-induced sexual dysfunction, or types of drugs from lipid-lowering agents to poisons antidotes. This bimonthly journal"s articles are timely, succinct and fully referenced