糖尿病神经病变患者抑郁、焦虑和疼痛感知的关系

IF 1 4区 医学 Q3 EMERGENCY MEDICINE
Signa Vitae Pub Date : 2021-09-15 DOI:10.22514/sv.2021.156
Maria Nianiarou, Zoi Gambopoulou, D. Solomou, M. Karathanou, D. Papadopoulou, E. Stavropoulou
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引用次数: 1

摘要

引言:糖尿病神经病变是糖尿病的常见并发症,发生在25-50%的患者中,大约一半的患者的临床表现为疼痛。与此同时,有许多研究证实了糖尿病患者精神障碍的高患病率,最近的研究表明这种双向关系似乎存在。在这篇综述中,我们检查了关于焦虑和抑郁在糖尿病神经病变中的作用的现有文献。方法:利用PubMed作为我们的搜索引擎,我们对过去十年的现有文献进行了搜索。使用的关键词是“抑郁”、“焦虑”、“疼痛”和“糖尿病神经病变”。这项搜索使我们得到了189个结果,其中13个结果与我们的标准相关,并在本文中使用。结果:通过对现有文献的分析,我们引用了一些研究的结论,即抑郁症患者更容易患糖尿病。此外,焦虑和抑郁与并发症和更高的疼痛性神经病变患病率相关。在糖尿病患者中,焦虑和抑郁的症状与更多的疼痛独立相关。在病理生理学水平上,中枢神经系统细胞功能的紊乱,如中枢敏化和神经胶质细胞的变化,在神经性疼痛和抑郁症中都有发现。结论:这篇综述强调了糖尿病神经病变患者疼痛和抑郁之间的联系,并强调了焦虑和抑郁在神经性疼痛中的作用。随着对病理生理途径和临床表型的进一步研究,可以研究糖尿病神经病变疼痛的预防和治疗的新目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Relationship between depression, anxiety, and pain perception in diabetic neuropathy
Introduction: Diabetic neuropathy is a common complication of diabetes, occurring in 25–50% of patients, with pain partaking in the clinical picture of about half of the patients. At the same time, there are many studies confirming the high prevalence of mental disorders in diabetes patients, and recent research signifies the bidirectional relationship that seems to exist. In this review, we examined the existing literature regarding the role of anxiety and depression in diabetic neuropathy. Methods: Utilizing PubMed as our search engine, we performed a search of the existing literature of the last decade. The key-words used were “depression” “anxiety” “pain” and “diabetic neuropathy”. This search led us to 189 results, and out of those 13 were found to correlate with our criteria and were used in this paper. Results: From the analysis of the existing literature we cite studies concluding that people with depression are more susceptible to the development of diabetes. Moreover, anxiety and depression are correlated with complications and higher prevalence of painful neuropathy. In diabetic patients, symptoms of anxiety and depression are independently connected with more pain. At a pathophysiology level, disorders in the cellular function of the CNS, such as central sensitization and changes in neuroglia, are noticed both in neuropathic pain and depression. Conclusions: This review highlights the connection between pain and depression in patients with diabetic neuropathy, with emphasis on the effect of anxiety and depression in neuropathic pain. With the association with the pathophysiological pathways and the clinical phenotype further researched, new goals in the prevention and the treatment of pain in diabetic neuropathy can be studied.
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来源期刊
Signa Vitae
Signa Vitae 医学-急救医学
CiteScore
1.30
自引率
9.10%
发文量
0
审稿时长
3 months
期刊介绍: Signa Vitae is a completely open-access,peer-reviewed journal dedicate to deliver the leading edge research in anaesthesia, intensive care and emergency medicine to publics. The journal’s intention is to be practice-oriented, so we focus on the clinical practice and fundamental understanding of adult, pediatric and neonatal intensive care, as well as anesthesia and emergency medicine. Although Signa Vitae is primarily a clinical journal, we welcome submissions of basic science papers if the authors can demonstrate their clinical relevance. The Signa Vitae journal encourages scientists and academicians all around the world to share their original writings in the form of original research, review, mini-review, systematic review, short communication, case report, letter to the editor, commentary, rapid report, news and views, as well as meeting report. Full texts of all published articles, can be downloaded for free from our web site.
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