基于MS的组学方法在生态毒理学研究中的挑战和前景:对Gammarids哨兵片脚类的见解

Valentina Calabrese, A. Salvador, Y. Clément, Thomas Brunet, A. Espeyte, A. Chaumot, O. Geffard, D. Degli-Esposti, S. Ayciriex
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引用次数: 0

摘要

水生环境是最复杂的生物系统之一,因为所有营养级的生物体都可能暴露在多种污染物中。作为主要目标,生态毒理学通常通过研究哨点生物来调查有毒污染物对生态系统的影响。在过去的几十年里,基于质谱(MS)的组学方法已经扩展到实验室和野外暴露条件下的前哨物种。单一组学方法能够发现反映生物体健康状况的生物标志物。通过覆盖一组有限的分子级联,它们只能部分满足对复杂生态毒理学效应的理解。相比之下,可以通过多组学方法更全面地了解生态毒性途径。从这个角度来看,我们对水生生态毒理学中基于MS的单组学和多组学研究的进一步发展提供了最新的和关键的评估。作为案例,将审查有关Gammarids淡水片脚类、对污染物和环境变化敏感的非模式前哨生物以及下游生态系统的关键物种的文献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Challenges and perspectives in MS-based omics approaches for ecotoxicology studies: An insight on Gammarids sentinel amphipods
The aquatic environment is one of the most complex biosystems, as organism at all trophic levels may be exposed to a multitude of pollutants. As major goals, ecotoxicology typically investigates the impact of toxic pollutants on the ecosystems through the study of sentinel organisms. Over the past decades, Mass Spectrometry (MS)-based omics approaches have been extended to sentinel species both in laboratory and field exposure conditions. Single-omics approaches enable the discovery of biomarkers mirroring the health status of an organism. By covering a restricted set of the molecular cascade, they turn out to only partially satisfy the understanding of complex ecotoxicological effects. In contrast, a more complete understanding of the ecotoxicity pathways can be accessed through multi-omics approaches. In this perspective, we provide a state-of-the-art and a critical evaluation on further developments in MS-based single and multi-omics studies in aquatic ecotoxicology. As case example, literature regarding Gammarids freshwater amphipods, non-model sentinel organisms sensitive to pollutants and environmental changes and crucial species for downstream ecosystems, will be reviewed.
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