脑梗死患者血清NSE、hs-CRP水平与NIHSS评分的相关性分析

中国基层医药 Pub Date : 2020-02-15 DOI:10.3760/CMA.J.ISSN.1008-6706.2020.04.007

Hui-Mei Wu

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Another 60 cases underwent health examination in our hospital from January 2017 to January 2019 were selected as the control group.Enzyme-linked immunosorbent assay (ELISA) was used to determine the content of NSE, and immunoturbidimetric assay was used to determine the content of hs-CRP.The changes of serum NSE and hs-CRP levels in the cerebral infarction group and control group, serum NSE, hs-CRP levels and NIHSS scores in different severity and infarction area, and the correlation between serum NSE and hs-CRP changes and NIHSS scores were compared. \n \n \nResults \nThe serum levels of NSE [(21.34±3.27)ng/mL] and hs-CRP [(10.48±2.14)mg/L] in the cerebral infarction group were significantly higher than those in the control group [(6.23±1.08)ng/mL, (2.83±0.46)mg/L] (t=34.061, 27.095, all P<0.05). The serum levels of NSE [(26.98±3.64) ng/mL], hs-CRP [(15.36±2.57)mg/L] and NIHSS score[(38.49±3.25)points] in the severe group were higher than those in the moderate group and mild group, which in the moderate group [(20.98±3.21)ng/mL, (10.25±2.09)mg/L and (22.18±3.48)points] were higher than those in the mild group [(12.64±2.78)ng/mL, (5.47±1.40)mg/L and (7.38±2.56)], the differences were statistically significant (F=14.975, 9.132, 15.873, all P<0.05). The serum levels of NSE [(25.43±3.35)ng/mL], hs-CRP [(16.54±2.71)mg/L] and NIHSS score[(37.34±3.75)points] in the large area group were higher than those in the small area group and lacunar infarction group, which in the small area group [(21.67±3.12)ng/mL, (10.86±2.21)mg/L and (21.25±3.26)points] were higher than those in the lacunar infarction group [(13.45±2.97)ng/mL, (4.79±1.35)mg/L and (8.49±2.15)points], the differences were statistically significant (F=13.241, 9.893, 17.482, all P<0.05). The serum levels of NSE and hs-CRP were positively correlated with NIHSS score (r=0.829, 0.713, all P<0.05). \n \n \nConclusion \nThe levels of serum NSE and hs-CRP in patients with cerebral infarction increase with the progression of the disease, and there is a linear positive correlation between NSE and hs-CRP and NIHSS score.It is considered that NSE and hs-CRP are of great value in evaluating the degree of neurological impairment, the severity of the disease and the size of the infarct. \n \n \nKey words: \nInfarction, middle cerebral artery; Neuron-specific enolase; C-reactive protein; Neurological deficit score","PeriodicalId":10226,"journal":{"name":"中国基层医药","volume":"27 1","pages":"412-416"},"PeriodicalIF":0.0000,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Analysis of correlation between serum NSE, hs-CRP levels and NIHSS score in patients with cerebral infarction\",\"authors\":\"Hui-Mei Wu\",\"doi\":\"10.3760/CMA.J.ISSN.1008-6706.2020.04.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective \\nTo investigate the correlation between the changes of serum neuron specific enolase (NSE) and hypersensitive C-reactive protein (hs-CRP) levels and the degree of neurological deficit (NIHSS) score in patients with cerebral infarction. \\n \\n \\nMethods \\nFrom January 2017 to January 2019, 63 patients with cerebral infarction admitted to Lishui Central Hospital were selected.According to NIHSS score, they were divided into 13 mild cases, 30 moderate cases and 20 severe cases.According to infarction area, they were divided into large area group (16 cases), small area group (27 cases) and lacunar infarction group (20 cases). 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The serum levels of NSE [(26.98±3.64) ng/mL], hs-CRP [(15.36±2.57)mg/L] and NIHSS score[(38.49±3.25)points] in the severe group were higher than those in the moderate group and mild group, which in the moderate group [(20.98±3.21)ng/mL, (10.25±2.09)mg/L and (22.18±3.48)points] were higher than those in the mild group [(12.64±2.78)ng/mL, (5.47±1.40)mg/L and (7.38±2.56)], the differences were statistically significant (F=14.975, 9.132, 15.873, all P<0.05). The serum levels of NSE [(25.43±3.35)ng/mL], hs-CRP [(16.54±2.71)mg/L] and NIHSS score[(37.34±3.75)points] in the large area group were higher than those in the small area group and lacunar infarction group, which in the small area group [(21.67±3.12)ng/mL, (10.86±2.21)mg/L and (21.25±3.26)points] were higher than those in the lacunar infarction group [(13.45±2.97)ng/mL, (4.79±1.35)mg/L and (8.49±2.15)points], the differences were statistically significant (F=13.241, 9.893, 17.482, all P<0.05). 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引用次数: 0

摘要

目的探讨脑梗死患者血清神经元特异性烯醇化酶(NSE)和超敏c反应蛋白(hs-CRP)水平变化与神经功能缺损程度(NIHSS)评分的相关性。方法选取2017年1月~ 2019年1月丽水市中心医院收治的脑梗死患者63例。根据NIHSS评分分为轻度13例、中度30例、重度20例。按梗死面积分为大面积组(16例)、小面积组(27例)和腔隙性梗死组(20例)。选取2017年1月至2019年1月在我院体检的患者60例作为对照组。采用酶联免疫吸附法(ELISA)测定NSE含量，采用免疫比浊法测定hs-CRP含量。比较脑梗死组和对照组血清NSE、hs-CRP水平的变化，不同严重程度和梗死区域血清NSE、hs-CRP水平和NIHSS评分的变化，以及血清NSE、hs-CRP变化与NIHSS评分的相关性。结果脑梗死组患者血清NSE[(21.34±3.27)ng/mL]、hs-CRP[(10.48±2.14)mg/L]水平显著高于对照组[(6.23±1.08)ng/mL、(2.83±0.46)mg/L] (t=34.061、27.095,P均<0.05)。重度组血清NSE[(26.98±3.64)ng/mL]、hs-CRP[(15.36±2.57)mg/L]、NIHSS评分[(38.49±3.25)分]均高于中度组和轻度组，其中中度组[(20.98±3.21)ng/mL、(10.25±2.09)mg/L、(22.18±3.48)分]高于轻度组[(12.64±2.78)ng/mL、(5.47±1.40)mg/L、(7.38±2.56)分]，差异均有统计学意义(F=14.975、9.132、15.873，均P<0.05)。的血清水平分析了无[(25.43±3.35)ng / mL], hs-CRP((16.54±2.71)mg / L)和署分数((37.34±3.75)分)在大面积组高于小面积组和腔隙梗死组,在小区域集团[(21.67±3.12)ng / mL, mg / L(10.86±2.21)和(21.25±3.26)分)都高于腔隙梗死组(ng / mL(13.45±2.97),(4.79±1.35)mg / L和(8.49±2.15)分),差异具有统计学意义(F = 13.241, 9.893, 17.482, P < 0.05)。血清NSE、hs-CRP水平与NIHSS评分呈正相关(r=0.829、0.713,P均<0.05)。结论脑梗死患者血清NSE和hs-CRP水平随病情进展而升高，NSE与hs-CRP及NIHSS评分呈线性正相关。认为NSE和hs-CRP在评价神经功能损害程度、疾病严重程度和梗死面积方面具有重要价值。关键词:脑梗死;大脑中动脉;特异性神经元烯醇酶;c反应蛋白;神经功能缺损评分

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Analysis of correlation between serum NSE, hs-CRP levels and NIHSS score in patients with cerebral infarction

Objective To investigate the correlation between the changes of serum neuron specific enolase (NSE) and hypersensitive C-reactive protein (hs-CRP) levels and the degree of neurological deficit (NIHSS) score in patients with cerebral infarction. Methods From January 2017 to January 2019, 63 patients with cerebral infarction admitted to Lishui Central Hospital were selected.According to NIHSS score, they were divided into 13 mild cases, 30 moderate cases and 20 severe cases.According to infarction area, they were divided into large area group (16 cases), small area group (27 cases) and lacunar infarction group (20 cases). Another 60 cases underwent health examination in our hospital from January 2017 to January 2019 were selected as the control group.Enzyme-linked immunosorbent assay (ELISA) was used to determine the content of NSE, and immunoturbidimetric assay was used to determine the content of hs-CRP.The changes of serum NSE and hs-CRP levels in the cerebral infarction group and control group, serum NSE, hs-CRP levels and NIHSS scores in different severity and infarction area, and the correlation between serum NSE and hs-CRP changes and NIHSS scores were compared. Results The serum levels of NSE [(21.34±3.27)ng/mL] and hs-CRP [(10.48±2.14)mg/L] in the cerebral infarction group were significantly higher than those in the control group [(6.23±1.08)ng/mL, (2.83±0.46)mg/L] (t=34.061, 27.095, all P<0.05). The serum levels of NSE [(26.98±3.64) ng/mL], hs-CRP [(15.36±2.57)mg/L] and NIHSS score[(38.49±3.25)points] in the severe group were higher than those in the moderate group and mild group, which in the moderate group [(20.98±3.21)ng/mL, (10.25±2.09)mg/L and (22.18±3.48)points] were higher than those in the mild group [(12.64±2.78)ng/mL, (5.47±1.40)mg/L and (7.38±2.56)], the differences were statistically significant (F=14.975, 9.132, 15.873, all P<0.05). The serum levels of NSE [(25.43±3.35)ng/mL], hs-CRP [(16.54±2.71)mg/L] and NIHSS score[(37.34±3.75)points] in the large area group were higher than those in the small area group and lacunar infarction group, which in the small area group [(21.67±3.12)ng/mL, (10.86±2.21)mg/L and (21.25±3.26)points] were higher than those in the lacunar infarction group [(13.45±2.97)ng/mL, (4.79±1.35)mg/L and (8.49±2.15)points], the differences were statistically significant (F=13.241, 9.893, 17.482, all P<0.05). The serum levels of NSE and hs-CRP were positively correlated with NIHSS score (r=0.829, 0.713, all P<0.05). Conclusion The levels of serum NSE and hs-CRP in patients with cerebral infarction increase with the progression of the disease, and there is a linear positive correlation between NSE and hs-CRP and NIHSS score.It is considered that NSE and hs-CRP are of great value in evaluating the degree of neurological impairment, the severity of the disease and the size of the infarct. Key words: Infarction, middle cerebral artery; Neuron-specific enolase; C-reactive protein; Neurological deficit score

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来源期刊

中国基层医药

CiteScore

0.10

自引率

0.00%

发文量

32251

期刊介绍： Since its inception, the journal "Chinese Primary Medicine" has adhered to the development strategy of "based in China, serving the grassroots, and facing the world" as its publishing concept, reporting a large amount of the latest medical information at home and abroad, prospering the academic field of primary medicine, and is praised by readers as a medical encyclopedia that updates knowledge. It is a core journal in China's medical and health field, and its influence index (CI) ranks Q2 in China's academic journals in 2022. It was included in the American Chemical Abstracts in 2008, the World Health Organization Western Pacific Regional Medical Index (WPRIM) in 2009, and the Japan Science and Technology Agency Database (JST) and Scopus Database in 2018, and was included in the Wanfang Data-China Digital Journal Group and the China Academic Journal Comprehensive Evaluation Database.