不对称反应中聚合物负载脯氨酸衍生催化剂的研究进展

IF 0.9 Q4 CHEMISTRY, PHYSICAL

Current Organocatalysis Pub Date : 2023-02-24 DOI:10.2174/2213337210666230224115814

S. Anas, Shajahan Rubina, Sarang Rithwik, Ramakrishnan Roopak

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引用次数: 0

摘要

过去二十年见证了有机催化的巨大发展，特别是在广泛的有机过程中使用脯氨酸和相关催化剂。除此之外，有机催化剂在合适的载体系统上的多相化也成为解决与经典有机催化剂相关的一些主要缺点的有效方法。特别是聚合物固定化催化剂在反应条件下非常稳定，具有优异的可回收性和可重复使用性。此外，这种方法提供了绿色化学标准，从而支持大规模工业制造过程。本文综述了聚合物固定化脯氨酸衍生系统作为有效的有机催化剂在Aldol、Michael、Mannich、环化反应等中的各种不对称转化的进展。

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Recent advances in polymer-supported proline-derived catalysts for asymmetric reactions

The last two decades have witnessed tremendous growth in organocatalysis, especially using proline and related catalysts in a wide range of organic processes. Along with this, the heterogenization of organocatalysts over suitable support systems also emerged as an effective approach for addressing some of the major drawbacks associated with classical organocatalysts. Polymer-immobilized catalysts, in particular, are extremely stable under reaction conditions with excellent recyclability and reusability. Moreover, this approach offers green chemistry standards and is, thereby, supportive of large-scale industrial manufacturing processes. This article summarises the developments using polymer immobilized proline-derived systems as efficient organocatalysts for various asymmetric transformations in Aldol, Michael, Mannich, cyclization reactions, etc.

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来源期刊

Current Organocatalysis CHEMISTRY, PHYSICAL-

CiteScore

2.00

自引率

0.00%

发文量

期刊介绍： Current Organocatalysis is an international peer-reviewed journal that publishes significant research in all areas of organocatalysis. The journal covers organo homogeneous/heterogeneous catalysis, innovative mechanistic studies and kinetics of organocatalytic processes focusing on practical, theoretical and computational aspects. It also includes potential applications of organocatalysts in the fields of drug discovery, synthesis of novel molecules, synthetic method development, green chemistry and chemoenzymatic reactions. This journal also accepts papers on methods, reagents, and mechanism of a synthetic process and technology pertaining to chemistry. Moreover, this journal features full-length/mini review articles within organocatalysis and synthetic chemistry. It is the premier source of organocatalysis and synthetic methods related information for chemists, biologists and engineers pursuing research in industry and academia.