高分辨率计算机断层扫描胸部诊断2019冠状病毒病的敏感性和特异性:与逆转录酶聚合酶链反应的回顾性相关性

R. Shrestha, M. Gautam
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引用次数: 0

摘要

背景:2019冠状病毒病于2019年12月在中国武汉市突然爆发。及早发现病人对控制疾病传播至关重要。本研究旨在评估与逆转录-聚合酶链反应相比,高分辨率胸部计算机断层扫描检测2019冠状病毒病的敏感性、特异性和实用性。材料和方法:本研究是一项回顾性单中心分析研究,经诺贝尔医学院教学医院机构审查委员会伦理批准,于2021年2月至2021年6月在诺贝尔医学院进行了为期5个月的第二波Covid - 19。所有临床疑似患者均在1周时差内进行了高分辨率胸部计算机断层扫描和逆转录-聚合酶链反应。在逆转录-聚合酶链反应结果可用之前,报道了高分辨率计算机断层胸片扫描。结果:在连续342例患者中(男性195例,女性147例,平均年龄64岁),逆转录聚合酶链反应阳性183例(53.5%)。在逆转录聚合酶链反应阳性的患者中,常见的高分辨率计算机断层胸片特征是双侧胸膜下和周围磨玻璃影伴间隔增厚(疯狂铺路)。与逆转录聚合酶链反应相比,敏感性为91.8%,特异性为67.2%。结论:本研究揭示了高分辨率ct胸部扫描准确诊断冠状病毒病2019的高灵敏度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sensitivity and Specificity of High Resolution Computed Tomography Chest in Diagnosing Corona Virus Disease 2019: A Retrospective Correlation with Reverse Transcriptase Polymerase Chain Reaction
Background: Corona Virus Disease 2019came into existence in December 2019, as a sudden outbreak inthe city of Wuhan, China. Early identification of the patient is vitalto control disease transmission.This study is aimed at estimatingthe sensitivity, specificity, and practicability of Highresolution computed tomography chest in detecting Corona Virus Disease 2019 compared with a Reverse transcriptase-polymerase chain reaction. Materials and Methods: This was a retrospective single-center analytical study conducted at Nobel Medical Collegefor5 months during the second wave of Covid 19 from Feb 2021 to June 2021 after ethical approval from the Institutional Review Committee of Nobel Medical College Teaching Hospital. All clinically suspected patients who had undergoneHigh-resolution computed tomography chest and Reverse transcriptase-polymerase chain reaction within a 1-week time difference were included. High-resolution computed tomography chest scan was reported before Reverse transcriptase-polymerase chain reaction results became available. Results: Among 342 consecutive patients (195 male and 147 females, mean age 64), Reverse transcriptase-polymerase chain reaction was positive in 183 (53.5%) cases. Common High-resolution computed tomography chest features significantly more common in Reverse transcriptase-polymerase chain reaction positive patients were bilateral subpleural and peripheral ground-glass opacities with septal thickening(crazy paving). In comparison with Reverse transcriptase-polymerase chain reaction, the sensitivity was 91.8% and specificity 67.2%. Conclusion: This study revealed the high sensitivity of high-resolution computed tomography chest scansin accurately diagnosingCorona Virus Disease 2019.
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