功能性肾靶向纳米药物脂质体的构建及其对狼疮性肾炎的治疗作用

Nanoscience and Nanotechnology Letters Pub Date : 2020-12-01 DOI:10.1166/NNL.2020.3262

Dagui Chen, Fusheng Shang, Shuyang Zhang, Danhuan Zhang

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引用次数: 0

摘要

本研究的主要目的是探讨负载羟氯喹的OX7纳米脂质体对小鼠系统性红斑狼疮(SLE)疾病模型的治疗作用。修饰OX7单克隆抗体使载羟基氯喹的OX7纳米脂质体靶向肾系膜细胞。采用尾静脉注射功能纳米脂质体治疗SLE小鼠模型，观察其对狼疮肾炎和合并肺炎的治疗效果。我们的研究表明，慢性移植物抗宿主病狼疮性肾炎小鼠模型具有与人SLE相似的肾脏病理损害特征，可用于相关研究。本实验制备的功能性纳米脂质体对模型小鼠的肺炎症状和发病率均有明显的缓解和降低作用。

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Construction of Functional Renal Targeting Nano Drug Liposome and Its Effect on Lupus Nephritis

The main purpose of this study was to explore treatment effect of hydroxychloroquine-loaded OX7 nanoliposomes in murine systemic lupus erythematosus (SLE) disease model. Modification of OX7 monoclonal antibody conferred hydroxychloroquine-loaded OX7 nanoliposomes targeting to renal mesangial cells. The SLE mice models were treated with functional nano liposome via tail vein injection, and then the therapeutic effects on lupus nephritis and complicated pneumonia were evaluated. Our research showed that chronic graft versus host disease lupus nephritis mice model has similar characteristic features of renal pathological damage with human SLE, and is reliable for related study. The symptoms and incidence of pneumonia in model mice were significantly alleviated and reduced after treatment with functional nano liposomes prepared in this experiment.

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来源期刊

Nanoscience and Nanotechnology Letters Physical, Chemical & Earth Sciences-MATERIALS SCIENCE, MULTIDISCIPLINARY

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审稿时长

2.6 months