用于生成活性氧的金属-有机框架

IF 6.1 Q2 CHEMISTRY, PHYSICAL
Hudson A. Bicalho, Victor Quezada-Novoa, Ashlee J. Howarth
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引用次数: 5

摘要

活性氧(ROS)是由氧衍生的高活性分子,是天然产生的,在生物过程中发挥重要作用。同时,活性氧是高级氧化工艺(AOPs)的基础,可用于多种工业应用,包括水处理和有机合成。此外,涉及癌细胞中ROS靶向产生的抗癌疗法通过促进氧化应激,从而促进细胞死亡,在体外和体内显示出有希望的结果。然而,时至今日,开发同时易于合成、低成本、无毒和高效的催化剂和系统仍然是一个挑战。考虑到这一点,金属-有机框架(MOFs)作为一类相对较新的配位聚合物,可能会显示出所有这些特性和许多其他特性,包括可调结构、广泛的孔隙率和高表面积。正因为如此,近年来,用于产生ROS的MOFs和MOF基材料的设计和合成引起了人们的关注。在这篇综述中,我们总结了MOFs或MOF基材料通过产生ROS在AOP和生物系统中作为催化剂的开发和使用的最新进展,为有希望的结果和未来的研究方向提供了启示。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metal–organic frameworks for the generation of reactive oxygen species
Reactive oxygen species (ROS) are highly reactive molecules derived from oxygen, which are naturally generated and play essential roles in biological processes. At the same time, ROS are the basis of advanced oxidation processes (AOPs), which can be used for multiple applications of industrial interest, including water treatment and organic synthesis. Additionally, anti-cancer therapies that involve the targeted production of ROS in cancerous cells have shown promising results in vitro and in vivo by promoting oxidative stress and, hence, cell death. However, up to this day, the development of catalysts and systems that are, at the same time, easily synthesized, low-cost, nontoxic, and highly effective remains a challenge. With that in mind, metal–organic frameworks (MOFs), a relatively new class of coordination polymers, may display all these characteristics and many others, including tunable structure, extensive porosity, and high surface areas. Because of that, the design and synthesis of MOFs and MOF-based materials for the generation of ROS has garnered attention in recent years. In this review, we summarize recent advances in the development and use of MOFs or MOF-based materials as catalysts in AOPs and biological systems through the generation of ROS, shining light on promising results and future research directions.
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