纳米脂质载体包裹小麦胚芽油的贮藏稳定性

IF 1.4 Q4 NANOSCIENCE & NANOTECHNOLOGY

Journal of Nanostructures Pub Date : 2020-04-01 DOI:10.22052/JNS.2020.02.007

Mojgan Mirtalebi, A. Rajaei, M. Bahmaei, A. Khosroushahi

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引用次数: 1

摘要

本研究旨在研究表面活性剂的组成对含小麦胚芽油的纳米结构脂质载体(nnlcs)物理性质的影响，并探讨表面活性剂的组成和pH对纳米结构脂质载体(nnlcs)氧化稳定性的影响。结果表明，最小粒径为52.7 nm, poloxer -NLC与脂质比为1:1 (Polox-NLC-1)。Polox-NLC-1不仅在贮存过程中表现出良好的稳定性，而且在差示扫描量热分析(DSC)中显示出合适的物理结构。氧化稳定性实验结果表明，NLCs比O/W乳液更能有效地保护WGO不被氧化。此外，poloxmer与脂质比为2:1的NLC (Polox-NLC-2)具有良好的氧化稳定性。此外，以波洛沙姆为非离子表面活性剂制备的NLC在高pH下具有更高的氧化稳定性，而以十二烷基硫酸钠(SDS)为离子表面活性剂制备的NLC在低pH下具有更高的氧化稳定性。这些结果表明，NLC可以作为生物活性物质来源的有效递送和保护系统。

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Storage Stability of Wheat Germ Oil Encapsulated within Nanostructured Lipid Carriers

The present study aimed to evaluate the effect of surfactant composition on the physical properties of nanostructured lipid carriers (NLCs) containing wheat germ oil (WGO) and to investigate the influence of both surfactant composition and pH on the oxidative stability of WGO encapsulated within the NLCs. The results showed that the smallest particle size (52.7 nm) was related to the NLC with the poloxamer-to-lipid ratio of 1:1 (Polox-NLC-1). Polox-NLC-1 not only showed good stability during storage, but also indicated a suitable physical structure from differential scanning calorimetry (DSC) analysis. The oxidative stability results indicated that the NLCs were more successful than O/W emulsion in protecting the WGO from oxidation. Additionally, the oxidative stability of the NLC with the poloxamer-to-lipid ratio of 2:1 (Polox-NLC-2) looked promising. Furthermore, NLCs prepared with the surfactant of poloxamer as a non-ionic surfactant had greater oxidative stability at high pH, and NLC prepared with sodium dodecyl sulfate (SDS) as an ionic surfactant had greater oxidative stability at low pH. These findings indicated that NLC could be an effective delivery and protection system for the WGO as a source of bioactive compounds.

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来源期刊

Journal of Nanostructures NANOSCIENCE & NANOTECHNOLOGY-

CiteScore

2.60

自引率

0.00%

发文量

审稿时长

7 weeks

期刊介绍： Journal of Nanostructures is a medium for global academics to exchange and disseminate their knowledge as well as the latest discoveries and advances in the science and engineering of nanostructured materials. Topics covered in the journal include, but are not limited to the following: Nanosystems for solar cell, energy, catalytic and environmental applications Quantum dots, nanocrystalline materials, nanoparticles, nanocomposites Characterization of nanostructures and size dependent properties Fullerenes, carbon nanotubes and graphene Self-assembly and molecular organization Super hydrophobic surface and material Synthesis of nanostructured materials Nanobiotechnology and nanomedicine Functionalization of nanostructures Nanomagnetics Nanosensors.