基于可再生聚合物的药物输送系统:一个概念性的简短回顾

Q2 Materials Science

Polymers from Renewable Resources Pub Date : 2022-02-01 DOI:10.1177/20412479221107469

M. Khodadadi Yazdi, K. Jabbour, S. Sajadi, Amin Esmaeili

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引用次数: 5

摘要

人们越来越关注传统合成聚合物对环境和健康的危害。这些聚合物是不可持续的，因为它们的生产过程依赖于化石原料和能源。经济效益和良好的物理化学和机械性能使合成聚合物在从包装到生物医药的广泛应用中得到了应用。另一方面，现代化学为我们提供了宝贵的工具来制造具有定制特性的明确定义的聚合物，这些聚合物可用于生物医学领域，如设计先进的药物输送系统(dds)。事实上，聚合物是大多数新型dds不可缺少的组成部分。然而，这种dds的原材料和聚合物构建块的可持续性问题仍未得到解决。此外，dds可持续构建块的有效和适当降解性对其在人体中的清除至关重要。因此，可持续发展的dds对可降解高分子材料的开发提出了很高的要求。这一观点提供了可持续聚合物的总体概述，并强调了它们在设计新型dds方面的潜在应用。讨论了尚未解决的挑战和未来的前景，并提出了可能的解决方案。

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Drug delivery systems based on renewable polymers: A conceptual short review

There are ever increasing concerns about environmental and health hazards of conventional synthetic polymers. These polymers are not sustainable because their production process relies on fossil-based feedstocks and energy sources. Economic benefits and beneficial physicochemical and mechanical properties have made synthetic polymers to be used in wide range of applications from packaging to biomedicine. On the other hand, modern chemistry has provided us with invaluable tools to make well-defined polymers with tailored properties which can be used in biomedical filed such as designing advanced drug delivery systems (DDSs). In fact, polymers are indispensable constituents of most of novel DDSs. However, sustainability concerns about raw materials and polymeric building blocks of such DDSs, remains unsolved. In addition, efficient and proper degradability of sustainable building blocks of DDSs is important for their clearance from human body. Accordingly, development of sustainable and biodegradable polymeric materials is highly demanding in development of sustainable DDSs. This perspective provides a general overview on sustainable polymers and highlights their potential applications in designing novel DDSs. Unsolved challenges and future prospects are discussed accompanied by offering potential solutions.

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来源期刊

Polymers from Renewable Resources Materials Science-Polymers and Plastics

CiteScore

3.50

自引率

0.00%

发文量

期刊介绍： Polymers from Renewable Resources, launched in 2010, publishes leading peer reviewed research that is focused on the development of renewable polymers and their application in the production of industrial, consumer, and medical products. The progressive decline of fossil resources, together with the ongoing increases in oil prices, has initiated an increase in the search for alternatives based on renewable resources for the production of energy. The prevalence of petroleum and carbon based chemistry for the production of organic chemical goods has generated a variety of initiatives aimed at replacing fossil sources with renewable counterparts. In particular, major efforts are being conducted in polymer science and technology to prepare macromolecular materials based on renewable resources. Also gaining momentum is the utilisation of vegetable biomass either by the separation of its components and their development or after suitable chemical modification. This journal is a valuable addition to academic, research and industrial libraries, research institutions dealing with the use of natural resources and materials science and industrial laboratories concerned with polymer science.