COVID-19患者与健康人群呼吸道微生物多样性比较

IF 1.1 4区医学 Q4 VIROLOGY

Acta virologica Pub Date : 2023-06-22 DOI:10.3389/av.2023.11664

Klaudia Babišová, Patrik Krumpolec, Dominik Hadžega, P. Sabaka, P. Jackuliak, G. Minárik, M. Hyblová

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引用次数: 0

摘要

自2019年底爆发以来，SARS-CoV-2病毒一直是许多研究感兴趣的主要主题。临床表现从无症状到轻、重度不等。发生严重COVID-19的主要风险因素是年龄和合并症，尽管年轻人也会患严重的COVID-19。其中一种解释可能是呼吸道微生物群的组成。本文综述了COVID-19感染期间呼吸道微生物组及其变化的相关研究。呼吸道微生物群有助于塑造免疫力，据推测它可以影响几种病毒感染的结果。几项研究表明，COVID-19患者与健康个体之间呼吸道微生物组成存在差异。呼吸道微生物组的多样性随着COVID-19严重程度的增加而减少。

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Comparison of microbial diversity of respiratory tract between COVID-19 patients and healthy population

Since its outbreak in late 2019, the SARS-CoV-2 virus has been the main subject of interest for a number of studies. Clinical manifestations are ranging from asymptomatic to mild and severe. Major risk factors for developing severe COVID-19 are age and comorbidities, although younger people suffer from severe COVID-19 as well. One of the explanations for why can be the composition of respiratory tract microbiota. In this article, we review studies linking respiratory tract microbiome and its changes during COVID-19 infection. The respiratory tract microbiome helps shape immunity and it is assumed that it can affect the outcome of several viral infections. Several studies show differences in the microbial composition of the respiratory tract between COVID-19 patients and healthy individuals. The diversity of the respiratory tract microbiome is reduced with increasing severity of COVID-19.

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来源期刊

Acta virologica 医学-病毒学

CiteScore

3.10

自引率

11.80%

发文量

审稿时长

>12 weeks

期刊介绍： Acta virologica is an international journal of predominantly molecular and cellular virology. Acta virologica aims to publish papers reporting original results of fundamental and applied research mainly on human, animal and plant viruses at cellular and molecular level. As a matter of tradition, also rickettsiae are included. Areas of interest are virus structure and morphology, molecular biology of virus-cell interactions, molecular genetics of viruses, pathogenesis of viral diseases, viral immunology, vaccines, antiviral drugs and viral diagnostics.