一例青年免疫功能正常人模拟胆汁性肝炎急性发作的肝脾T细胞淋巴瘤

IF 1.5 Q3 GASTROENTEROLOGY & HEPATOLOGY
F. Metelli, R. Solimando, L. Alemanni, R. Gafà, G. Marasco
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引用次数: 1

摘要

我们在此报告一例肝脾T细胞淋巴瘤(HSTCL)偶然发现于一名30岁男子,他在脚踝创伤后来到急诊室。入院时,实验室检查显示肝酶异常和全血细胞减少,影像学显示轻度肝脾肿大。住院期间,患者的临床状况迅速恶化,同时伴有胆汁淤积酶增加、严重黄疸和全血细胞减少症恶化。肝损伤的原因,包括许多传染病,一直被探索,直到通过肝脏和骨髓活检诊断出HSTCL。随后,患者接受了六个周期的CHOP(环磷酰胺、羟基柔红霉素、oncovin和泼尼松或泼尼松)方案化疗,以及一个周期的Hyper CVAD(环磷酰胺、长春新碱、阿霉素、地塞米松)化疗,但尽管进行了积极的治疗,仍在诊断后2个月因疾病进展而死亡。在诊断急性胆汁淤积性肝炎并伴有肝脾肿大和细胞减少时,应考虑这种罕见疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hepatosplenic T-Cell Lymphoma Mimicking Acute Onset of Cholestatic Hepatitis in a Young Immunocompetent Man: A Case Report
We herein report a case of hepatosplenic T-cell lymphoma (HSTCL) incidentally found in a 30-year-old man who came to the emergency department after an ankle trauma. At admission, laboratory tests revealed abnormal liver enzymes and pancytopenia, and imaging showed mild hepatosplenomegaly. During hospitalization, the patient’s clinical condition worsened rapidly, with a concomitant increase in cholestatic enzymes, severe jaundice, and the worsening of pancytopenia. Causes of liver injury, including many infectious diseases, were explored until the diagnosis of HSTCL was made by liver and bone marrow biopsies. Subsequently, the patient underwent six cycles of chemotherapy with a CHOP (cyclophosphamide, hydroxydaunorubicin, oncovin and prednisone or prednisolone) regimen and one with Hyper-CVAD (fractionated cyclophosphamide, vincristine, doxorubicin, dexamethasone) but, despite this aggressive treatment, died due to disease progression 2 months after diagnosis. This rare disease should be considered in the diagnostic workup of acute cholestatic hepatitis presenting with concomitant hepatosplenomegaly and cytopenia.
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来源期刊
Gastroenterology Insights
Gastroenterology Insights GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
2.80
自引率
3.40%
发文量
35
审稿时长
10 weeks
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