青少年轻度外伤性脑损伤后纵向血流动力学改变模型

C. Thibeault, S. Thorpe, N. Canac, M. O'Brien, Mina Ranjbaran, S. Wilk, R. Hamilton
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引用次数: 5

摘要

对轻度创伤性脑损伤的定量生物标志物的需求是毋庸置疑的。对于青少年来说尤其如此,他们对这些伤害的恢复仍然知之甚少。然而,在这个人群中,很明显,血管系统明显受到轻度创伤性脑损伤的影响。此外,我们的研究小组最近证明,这种影响似乎显示出与严重创伤中发现的变化相似但相反的进展。通过测量青少年人群在高碳酸血症期间的经颅多普勒超声,提出了多个阶段的血流动力学功能障碍。在这里,我们通过拟合一组逆模型来从该工作中获得主要特征,从而创建了血流动力学响应的广义模型。由此产生的模型有助于定义轻度创伤性脑损伤后血流动力学恢复的多个阶段。这最终可以推广,可能为临床医生跟踪患者康复提供诊断工具,并最终产生更明智的决策和更好的结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A model of longitudinal hemodynamic alterations after mild traumatic brain injury in adolescents
There is an unquestionable need for quantitative biomarkers of mild traumatic brain injuries. Something that is particularly true for adolescents – where the recovery from these injuries is still poorly understood. However, within this population, it is clear that the vasculature is distinctly affected by a mild traumatic brain injury. In addition, our group recently demonstrated how that effect appears to show a progression of alterations similar but in contrast to that found in severe traumatic injuries. Through measuring an adolescent population with transcranial Doppler ultrasound during a hypercapnia challenge, multiple phases of hemodynamic dysfunction were suggested. Here, we create a generalized model of the hemodynamic responses by fitting a set of inverse models to the dominant features from that work. The resulting model helps define the multiple phases of hemodynamic recovery after a mild traumatic brain injury. This can eventually be generalized, potentially providing a diagnostic tool for clinicians tracking patient’s recovery, and ultimately, resulting in more informed decisions and better outcomes.
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