68Ga-SSA/18F-FDG PET/CT联合成像在神经内分泌肿瘤中的临床价值

中华核医学与分子影像杂志 Pub Date : 2020-01-25 DOI:10.3760/CMA.J.ISSN.2095-2848.2020.01.012

Shuai Zhao, Chao Cheng

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引用次数: 0

摘要

神经内分泌肿瘤（NEN）是起源于神经内分泌细胞或肽能神经元的肿瘤。NEN可在多种器官中发现，病理学异质性高，预后差异大。传统的影像学方法和病理活检在NEN的诊断中具有重要作用，但两者都有局限性。大多数NEN细胞高度表达几种肽受体，尤其是生长抑素受体（SSTR）。此外，它们中的一些由于具有高增殖活性而具有高糖酵解活性。68Ga生长抑素类似物（68Ga-SSA）与18F-氟脱氧葡萄糖（18F-FDG）PET/CT显像相结合，可以综合评价NEN中SSTR的表达和糖酵解活性，为诊断、治疗、监测和预后提供有效信息。本文综述了68Ga-SSA/18F-FDG PET/CT联合成像在NEN患者中的研究进展。关键词：神经内分泌肿瘤；生长抑素；镓放射性同位素；正电子发射断层扫描；层析成像，X射线计算机；脱氧葡萄糖；趋势

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The clinical value of combined 68Ga-SSA/18F-FDG PET/CT imaging in neuroendocrine neoplasms

Neuroendocrine neoplasms (NEN) are tumors that originate from neuroendocrine cells or peptidergic neurons. NEN can be found in a variety of organs with high heterogeneity in pathology and large difference in prognosis. Conventional imaging methods and pathological biopsy have important roles in the diagnosis of NEN, while both of them have limitations. Most NEN cells highly express several peptide receptors, especially somatostatin receptors (SSTR). Moreover, some of them have high glycolysis activity because of high proliferative activity. 68Ga-somatostatin analogs (68Ga-SSA) combined with 18F-fluorodeoxyglucose (18F-FDG) PET/CT imaging can comprehensively evaluate both the expression of SSTR and the activity of glycolysis in NEN, providing effective information for diagnosis, treatment, monitoring and prognosis. This review summarizes the current studies of combined 68Ga-SSA/18F-FDG PET/CT imaging in patients with NEN. Key words: Neuroendocrine tumors; Somatostatin; Gallium radioisotopes; Positron-emission tomography; Tomography, X-ray computed; Deoxyglucose; Trends

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来源期刊

中华核医学与分子影像杂志核医学，分子影像

自引率

0.00%

发文量

5088

期刊介绍： Chinese Journal of Nuclear Medicine and Molecular Imaging (CJNMMI) was established in 1981, with the name of Chinese Journal of Nuclear Medicine, and renamed in 2012. As the specialized periodical in the domain of nuclear medicine in China, the aim of Chinese Journal of Nuclear Medicine and Molecular Imaging is to develop nuclear medicine sciences, push forward nuclear medicine education and basic construction, foster qualified personnel training and academic exchanges, and popularize related knowledge and raising public awareness. Topics of interest for Chinese Journal of Nuclear Medicine and Molecular Imaging include: -Research and commentary on nuclear medicine and molecular imaging with significant implications for disease diagnosis and treatment -Investigative studies of heart, brain imaging and tumor positioning -Perspectives and reviews on research topics that discuss the implications of findings from the basic science and clinical practice of nuclear medicine and molecular imaging - Nuclear medicine education and personnel training - Topics of interest for nuclear medicine and molecular imaging include subject coverage diseases such as cardiovascular diseases, cancer, Alzheimer’s disease, and Parkinson’s disease, and also radionuclide therapy, radiomics, molecular probes and related translational research.